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1
RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene.RADH是酿酒酵母的一个基因，编码一种参与DNA修复的假定DNA解旋酶。radH突变体的特征及该基因的序列。
Nucleic Acids Res. 1989 Sep 25;17(18):7211-9. doi: 10.1093/nar/17.18.7211.
2
The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene.酿酒酵母的超基因转换hpr5-1突变是SRS2/RADH基因的一个等位基因。
Genetics. 1991 Jan;127(1):75-85. doi: 10.1093/genetics/127.1.75.
3
The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism.酿酒酵母RAD30基因是大肠杆菌dinB和umuC的同源物，可被DNA损伤诱导，并在一种新的无差错复制后修复机制中发挥作用。
Genetics. 1997 Dec;147(4):1557-68. doi: 10.1093/genetics/147.4.1557.
4
An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae.在酿酒酵母中，一个必需基因ESR1对于有丝分裂细胞生长、DNA修复和减数分裂重组是必需的。
Nucleic Acids Res. 1994 Aug 11;22(15):3104-12. doi: 10.1093/nar/22.15.3104.
5
Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.在缺乏Sgs1和Srs2解旋酶的情况下，同源重组会导致细胞死亡。
Nat Genet. 2000 Jun;25(2):192-4. doi: 10.1038/76055.
6
Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome.酿酒酵母RAD5编码的DNA修复蛋白含有DNA解旋酶和锌结合序列基序，并影响基因组中简单重复序列的稳定性。
Mol Cell Biol. 1992 Sep;12(9):3807-18. doi: 10.1128/mcb.12.9.3807-3818.1992.
7
Synergistic interactions between RAD5, RAD16 and RAD54, three partially homologous yeast DNA repair genes each in a different repair pathway.RAD5、RAD16和RAD54之间的协同相互作用，这三个部分同源的酵母DNA修复基因分别处于不同的修复途径中。
Radiat Res. 1994 Jul;139(1):24-33.
8
The Schizosaccharomyces pombe rhp3+ gene required for DNA repair and cell viability is functionally interchangeable with the RAD3 gene of Saccharomyces cerevisiae.粟酒裂殖酵母中DNA修复和细胞活力所需的rhp3+基因在功能上可与酿酒酵母的RAD3基因互换。
Nucleic Acids Res. 1992 May 11;20(9):2327-34. doi: 10.1093/nar/20.9.2327.
9
Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae.酿酒酵母中控制细胞周期对DNA损伤反应的基因RAD17的克隆与特性分析
Nucleic Acids Res. 1996 May 1;24(9):1669-75. doi: 10.1093/nar/24.9.1669.
10
Allelism of PSO4 and PRP19 links pre-mRNA processing with recombination and error-prone DNA repair in Saccharomyces cerevisiae.PSO4和PRP19的等位性将酿酒酵母中的前体mRNA加工与重组及易错DNA修复联系起来。
Nucleic Acids Res. 1996 Oct 15;24(20):4009-14. doi: 10.1093/nar/24.20.4009.

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The separation pin distinguishes the pro- and anti-recombinogenic functions of Saccharomyces cerevisiae Srs2.分离钉区分了酿酒酵母 Srs2 的促进和抗重组功能。
Nat Commun. 2023 Dec 8;14(1):8144. doi: 10.1038/s41467-023-43918-4.
2
Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase.酵母 PCNA 基因突变的遗传剖析导致 Srs2 解旋酶的调控募集。
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Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps.在缺乏由 Rad51 旁系同源物 Rad55 和 Rad57 形成的复合物的情况下组装的 Rad51 丝体，在 UV 诱导的 ssDNA 缺口上会被跨损伤 DNA 聚合酶竞争。
PLoS Genet. 2023 Feb 7;19(2):e1010639. doi: 10.1371/journal.pgen.1010639. eCollection 2023 Feb.
4
Repair of DNA double-strand breaks in plant meiosis: role of eukaryotic RecA recombinases and their modulators.植物减数分裂中DNA双链断裂的修复：真核生物RecA重组酶及其调节剂的作用
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5
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6
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Genes (Basel). 2021 Nov 18;12(11):1812. doi: 10.3390/genes12111812.
7
Srs2 and Pif1 as Model Systems for Understanding Sf1a and Sf1b Helicase Structure and Function.以 Srs2 和 Pif1 为模型系统，研究 Sf1a 和 Sf1b 解旋酶的结构与功能。
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8
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10
Role of the Srs2-Rad51 Interaction Domain in Crossover Control in .Srs2-Rad51 相互作用结构域在. 中的交叉控制作用
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本文引用的文献

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Codon selection in yeast.酵母中的密码子选择
J Biol Chem. 1982 Mar 25;257(6):3026-31.
2
The nucleotide sequence of the uvrD gene of E. coli.大肠杆菌uvrD基因的核苷酸序列。
Nucleic Acids Res. 1984 Jul 25;12(14):5789-99. doi: 10.1093/nar/12.14.5789.
3
Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast.点突变确定了保守的、内含于内含子中的TACTAAC盒是酵母中一个必需的剪接信号序列。
Cell. 1984 Mar;36(3):645-53. doi: 10.1016/0092-8674(84)90344-1.
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DNA sequence required for efficient transcription termination in yeast.酵母中高效转录终止所需的DNA序列。
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Unwinding and rewinding of DNA by the RecBC enzyme.RecBC酶对DNA的解旋和重新缠绕。
Cell. 1980 Nov;22(2 Pt 2):447-57. doi: 10.1016/0092-8674(80)90355-4.
6
Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene.包含染色体复制起点和TRP1基因的酵母DNA片段的序列。
Gene. 1980 Jul;10(2):157-66. doi: 10.1016/0378-1119(80)90133-x.
7
The E. coli uvrD gene product is DNA helicase II.大肠杆菌uvrD基因产物是DNA解旋酶II。
Mol Gen Genet. 1983;190(2):265-70. doi: 10.1007/BF00330649.
8
The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs.序列5'-AAUAAA-3'构成了猴病毒40（SV40）晚期mRNA聚腺苷酸化识别位点的一部分。
Cell. 1981 Apr;24(1):251-60. doi: 10.1016/0092-8674(81)90521-3.
9
A genetic study of x-ray sensitive mutants in yeast.酵母中X射线敏感突变体的遗传学研究。
Mutat Res. 1974 Sep;24(3):281-92. doi: 10.1016/0027-5107(74)90176-6.
10
The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes.由rec B、C基因指导的三磷酸腺苷依赖性脱氧核糖核酸酶从大肠杆菌中的分离与鉴定。
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RADH是酿酒酵母的一个基因，编码一种参与DNA修复的假定DNA解旋酶。radH突变体的特征及该基因的序列。

RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene.

作者信息

Aboussekhra A, Chanet R, Zgaga Z, Cassier-Chauvat C, Heude M, Fabre F

机构信息

Institut Curie-Biologie, Centre Universitaire, Orsay, France.

出版信息

Nucleic Acids Res. 1989 Sep 25;17(18):7211-9. doi: 10.1093/nar/17.18.7211.

DOI:10.1093/nar/17.18.7211
PMID:2552405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC334801/
Abstract

A new type of radiation-sensitive mutant of S. cerevisiae is described. The recessive radH mutation sensitizes to the lethal effect of UV radiations haploids in the G1 but not in the G2 mitotic phase. Homozygous diploids are as sensitive as G1 haploids. The UV-induced mutagenesis is depressed, while the induction of gene conversion is increased. The mutation is believed to channel the repair of lesions engaged in the mutagenic pathway into a recombination process, successful if the events involve sister-chromatids but lethal if they involve homologous chromosomes. The sequence of the RADH gene reveals that it may code for a DNA helicase, with a Mr of 134 kDa. All the consensus domains of known DNA helicases are present. Besides these consensus regions, strong homologies with the Rep and UvrD helicases of E. coli were found. The RadH putative helicase appears to belong to the set of proteins involved in the error-prone repair mechanism, at least for UV-induced lesions, and could act in coordination with the Rev3 error-prone DNA polymerase.

摘要

本文描述了一种新型的酿酒酵母辐射敏感突变体。隐性radH突变使处于G1期而非G2有丝分裂期的单倍体对紫外线辐射的致死效应敏感。纯合二倍体与G1单倍体一样敏感。紫外线诱导的诱变作用受到抑制，而基因转换的诱导作用增强。据信该突变将参与诱变途径的损伤修复导向重组过程，如果事件涉及姐妹染色单体则成功，但如果涉及同源染色体则致死。RADH基因的序列显示它可能编码一种DNA解旋酶，分子量为134 kDa。已知DNA解旋酶的所有共有结构域均存在。除了这些共有区域外，还发现与大肠杆菌的Rep和UvrD解旋酶有很强的同源性。RadH推定的解旋酶似乎属于参与易错修复机制的蛋白质组，至少对于紫外线诱导的损伤而言，并且可能与Rev3易错DNA聚合酶协同作用。