~12F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描和磁共振成像在腺样囊性癌患者中的诊断准确性。~
Diagnostic accuracy of F-FDG PET/CT and MR imaging in patients with adenoid cystic carcinoma.
机构信息
Department of Nuclear Medicine, University Duisburg-Essen, Medical Faculty, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Ulm, Frauensteige 12, 89070, Ulm, Germany.
出版信息
BMC Cancer. 2017 Dec 22;17(1):887. doi: 10.1186/s12885-017-3890-4.
BACKGROUND
The aim of this study was to evaluate the value of 18F-FDG PET/CT (PET/CT) and MRI for local and/or whole-body restaging of adenoid cystic carcinoma of the head and neck (ACC).
METHODS
Thirty-six patients with ACC underwent conventional MRI of the head and neck and a whole-body PET/CT and were analysed with regards to detection of a local tumor recurrence, lymph node or distant metastases. A consensus interpretation of all available imaging data was used as reference standard. Sensitivity, specificity, diagnostic accuracy, positive and negative predictive values were calculated for MRI and PET/CT.
RESULTS
The sensitivity of PET/CT and MRI was 96% (89%), specificity 89% (89%), PPV 96% (96%), NPV 89% (73%) and accuracy 94% (89%) for detection of local tumors. Additionally, PET/CT revealed lymph node metastases in one patient and distant metastases in 9/36 patients. In three patients secondary primaries were found.
CONCLUSIONS
Whole-body PET/CT in addition to MRI of the head and neck improves detection of local tumour and metastastic spread in ACC.
背景
本研究旨在评估 18F-FDG PET/CT（PET/CT）和 MRI 对头颈部腺样囊性癌（ACC）局部和/或全身分期的价值。
方法
36 例 ACC 患者行头颈部常规 MRI 和全身 PET/CT 检查，分析局部肿瘤复发、淋巴结或远处转移的检出情况。以所有可用影像学数据的综合解读为参考标准。计算 MRI 和 PET/CT 的敏感性、特异性、诊断准确性、阳性预测值和阴性预测值。
结果
PET/CT 和 MRI 检测局部肿瘤的敏感性分别为 96%（89%）、特异性 89%（89%）、PPV 96%（96%）、NPV 89%（73%）和准确性 94%（89%）。此外，PET/CT 还在 1 例患者中发现了淋巴结转移，在 36 例患者中发现了 9 例远处转移。在 3 例患者中发现了继发性原发性肿瘤。
结论
头颈部 MRI 联合全身 PET/CT 可提高 ACC 局部肿瘤和转移扩散的检出率。
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