Merriman John D, Aouizerat Bradley E, Cataldo Janine K, Dunn Laura B, Kober Kord, Langford Dale J, West Claudia, Cooper Bruce A, Paul Steven M, Miaskowski Christine
School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA.
School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA; Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Box 0794, San Francisco, CA 94143-0794, USA.
Eur J Oncol Nurs. 2015 Jun;19(3):251-9. doi: 10.1016/j.ejon.2014.11.004. Epub 2014 Dec 15.
Evaluate for associations between variations in genes involved in catecholaminergic, gamma-aminobutyric acid (GABA)-ergic, and serotonergic mechanisms of neurotransmission and attentional function latent classes.
This descriptive, longitudinal study was conducted at two radiation therapy departments. The sample included three latent classes of individuals with distinct trajectories of self-reported attentional function during radiation therapy, who were previously identified using growth mixture modeling among 167 oncology patients and 85 of their family caregivers. Multivariable models were used to evaluate for genotypic associations of neurotransmission genes with attentional function latent class membership, after controlling for covariates.
Variations in catecholaminergic (i.e., ADRA1D rs4815675, SLC6A3 rs37022), GABAergic (i.e., SLC6A1 rs2697138), and serotonergic (i.e., HTR2A rs2296972, rs9534496) neurotransmission genes were significant predictors of latent class membership in multivariable models.
Findings suggest that variations in genes that encode for three distinct but related neurotransmission systems are involved in alterations in attentional function. Knowledge of both phenotypic and genetic markers associated with alterations in attentional function can be used by clinicians to identify patients and family caregivers who are at higher risk for this symptom. Increased understanding of the genetic markers associated with alterations in attentional function may provide insights into the underlying mechanisms for this significant clinical problem.
评估参与儿茶酚胺能、γ-氨基丁酸（GABA）能和5-羟色胺能神经传递机制的基因变异与注意力功能潜在类别之间的关联。
这项描述性纵向研究在两个放射治疗科室进行。样本包括三类在放射治疗期间自我报告注意力功能轨迹不同的个体，这些个体先前是在167名肿瘤患者及其85名家庭护理人员中通过生长混合模型确定的。在控制协变量后，使用多变量模型评估神经传递基因与注意力功能潜在类别成员资格的基因型关联。
在多变量模型中，儿茶酚胺能（即ADRA1D rs4815675、SLC6A3 rs37022）、GABA能（即SLC6A1 rs2697138）和5-羟色胺能（即HTR2A rs2296972、rs9534496）神经传递基因的变异是潜在类别成员资格的显著预测因素。
研究结果表明，编码三种不同但相关神经传递系统的基因变异与注意力功能改变有关。临床医生可以利用与注意力功能改变相关的表型和基因标记知识，来识别有较高风险出现该症状的患者和家庭护理人员。对与注意力功能改变相关的基因标记的进一步了解，可能有助于深入了解这一重大临床问题的潜在机制。
