Koren Rachel, Duncan Alexis E, Munn-Chernoff Melissa A, Bucholz Kathleen K, Lynskey Michael T, Heath Andrew C, Agrawal Arpana
aDepartment of Psychology bGeorge Warren Brown School of Social Work, Washington University in St Louis cDepartment of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, Missouri, USA.
Psychiatr Genet. 2014 Feb;24(1):28-33. doi: 10.1097/YPG.0000000000000014.
We examined the association between 15 single nucleotide polymorphisms (SNPs) in HTR2A and characteristics of disordered eating, including weight/shape concerns, binge eating (with or without loss of control), and compensatory behaviors (purging and nonpurging). Whether a lifetime history of major depressive disorder (MDD) moderated or mediated this association was also investigated. A sample of 1533 twin women of White descent that were part of the Missouri Adolescent Female Twin Study was used. Data were collected using self-report responses to a semistructured interview. Logistic regression analyses were used to examine the association between weight/shape concerns, binge eating, and compensatory behaviors and SNPs (where carriers of the minor allele were coded as 1). Two SNPs, rs6561333 and rs2296972, showed a protective influence against binge eating, with rs2296972 being significant at a trend level after application of the false discovery rate. The SNP was not associated with MDD nor did MDD moderate its putative relation with binge eating. Pending replication, our analyses provide preliminary evidence for intronic SNPs in HTR2A and their association with binge eating. Given the well-documented role of serotonergic dysfunction in eating psychopathology, this report warrants considerable further study.
我们研究了5-羟色胺受体2A（HTR2A）基因中的15个单核苷酸多态性（SNP）与饮食失调特征之间的关联，这些特征包括对体重/体型的关注、暴饮暴食（无论有无失控）以及代偿行为（清除和非清除行为）。我们还研究了重度抑郁症（MDD）的终生病史是否调节或介导了这种关联。研究使用了密苏里青少年女性双胞胎研究中的1533名白人后裔双胞胎女性样本。数据通过对半结构化访谈的自我报告回答收集。逻辑回归分析用于检验对体重/体型的关注、暴饮暴食和代偿行为与SNP之间的关联（其中次要等位基因的携带者编码为1）。两个SNP，rs6561333和rs2296972，对暴饮暴食有保护作用，在应用错误发现率后，rs2296972在趋势水平上具有显著性。该SNP与MDD无关，MDD也未调节其与暴饮暴食的假定关系。在等待重复验证的情况下，我们的分析为HTR2A基因内含子SNP及其与暴饮暴食的关联提供了初步证据。鉴于血清素功能障碍在饮食心理病理学中已得到充分证明的作用，本报告值得进行大量进一步研究。
