Clark Simon, Hall Yper, Williams Ann
Microbiology Services, Public Health England, Porton Down, Salisbury SP4 0JG, United Kingdom.
Cold Spring Harb Perspect Med. 2014 Dec 18;5(5):a018572. doi: 10.1101/cshperspect.a018572.
The progression of the disease that follows infection of guinea pigs with Mycobacterium tuberculosis displays many features of human tuberculosis (TB), and the guinea pig model of TB has been used for more than 100 years as a research tool to understand and describe disease mechanisms. Changes in the bacterial burden and pathology following infection can be readily monitored and used to evaluate the impact of TB interventions. Demonstration of the protective efficacy of vaccines in the low-dose aerosol guinea pig model is an important component of the preclinical data package for novel vaccines in development, and there is a continual need to improve the model to facilitate progression of vaccines to the clinic. Development of better tools with which to dissect the immune responses of guinea pigs is a focus of current research.
豚鼠感染结核分枝杆菌后疾病的进展表现出许多人类结核病（TB）的特征，并且TB的豚鼠模型作为一种研究工具来理解和描述疾病机制已被使用了100多年。感染后细菌负荷和病理学的变化可以很容易地监测到，并用于评估TB干预措施的影响。在低剂量气溶胶豚鼠模型中证明疫苗的保护效力是正在研发的新型疫苗临床前数据包的一个重要组成部分，并且持续需要改进该模型以促进疫苗进入临床。开发更好的工具来剖析豚鼠的免疫反应是当前研究的一个重点。
