From the UCL Centre for Nephrology, Royal Free Hospital, London, UK, Division of Nephrology, Catholic University of the Sacred Heart, Rome, Italy, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK and Adult Nephrology Unit, Shaare Zedek Medical Center, Jerusalem, Israel From the UCL Centre for Nephrology, Royal Free Hospital, London, UK, Division of Nephrology, Catholic University of the Sacred Heart, Rome, Italy, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK and Adult Nephrology Unit, Shaare Zedek Medical Center, Jerusalem, Israel
From the UCL Centre for Nephrology, Royal Free Hospital, London, UK, Division of Nephrology, Catholic University of the Sacred Heart, Rome, Italy, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK and Adult Nephrology Unit, Shaare Zedek Medical Center, Jerusalem, Israel From the UCL Centre for Nephrology, Royal Free Hospital, London, UK, Division of Nephrology, Catholic University of the Sacred Heart, Rome, Italy, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK and Adult Nephrology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
QJM. 2015 Jul;108(7):561-8. doi: 10.1093/qjmed/hcu251. Epub 2014 Dec 17.
Kidney stone disease has an estimated prevalence of around 10%. Genetic as well as environmental factors are thought to play an important role in the pathogenesis of renal stones.
The aim of our study was to analyse and report the main characteristics of patients with kidney stones attending a large UK metabolic stone clinic in London between 1995 and 2012.
A cross-sectional study.
Analysis of data from stone formers attending the University College and Royal Free Hospitals' metabolic stone clinic from 1995 to 2012. Demographic, clinical, dietary and biochemical characteristics have been summarized and analysed for men and women separately; trends over time have also been analysed.
Of the 2861 patients included in the analysis, 2016 (70%) were men with an average age of 47 years (range 18-87 years) and median duration of disease of 6 years (range 0-60 years). The prevalence of low urine volume, hypercalciuria, hyperoxaluria, hyperuricosuria and hypocitraturia was 5.6%, 38%, 7.9%, 18% and 23%, respectively. The prevalence of several risk factors for stones increased over time. The majority of stones were mixed, with around 90% composed of calcium salts in varying proportion.
Our findings in a large cohort of patients attending a London-based stone clinic over the past 20 years show differences in distributions of risk factors for stones for men and women, as well as metabolic profiles and stone composition. The impact of most risk factors for stones appeared to change over time.
肾结石疾病的患病率约为 10%。遗传和环境因素被认为在肾结石的发病机制中起重要作用。
我们的研究目的是分析和报告 1995 年至 2012 年间在英国伦敦一家大型代谢性结石诊所就诊的肾结石患者的主要特征。
横断面研究。
分析 1995 年至 2012 年期间在大学学院和皇家自由医院代谢性结石诊所就诊的结石形成者的数据。总结和分析了男性和女性的人口统计学、临床、饮食和生化特征；还分析了随时间的趋势。
在纳入分析的 2861 名患者中，2016 名（70%）为男性，平均年龄为 47 岁（年龄 18-87 岁），中位疾病持续时间为 6 年（0-60 年）。尿体积低、高钙尿症、高草酸尿症、高尿酸尿症和低柠檬酸尿症的患病率分别为 5.6%、38%、7.9%、18%和 23%。多种结石危险因素的患病率随时间增加。大多数结石为混合性结石，约 90%由不同比例的钙盐组成。
我们在过去 20 年在伦敦一家基于诊所的大型患者队列中发现，男性和女性的结石危险因素分布、代谢特征和结石成分存在差异。大多数结石危险因素的影响似乎随时间而变化。
