Cicerello Elisa, Mangano Mario, Cova Gian Davide, Merlo Franco, Maccatrozzo Luigi
Unità Complessa di Urologia, Ospedale Ca'Foncello, Treviso.
Arch Ital Urol Androl. 2016 Oct 5;88(3):208-211. doi: 10.4081/aiua.2016.3.208.
Fifty-four patients with infected renal lithiasis underwent complete metabolic evaluation searching for underlying factors contributing to stone formation including urine analysis and culture. Metabolic abnormalities were significantly more present in patients with mixed infected stones (struvite+/-apatite and calcium oxalate) than in patients with pure infected stones (struvite+/-carbonate apatite): hypercalciuria in 40%, hyperoxaluria in 34% and hyperuricosuria in 28% (p < 0.05). Urinary excretion of citrate was low in both groups without statistically significant difference (238+/-117 mg/24 h vs 214+/-104 mg/24/h, t = 0.72, p = 0.5). The few metabolic abnormalities present in patients with pure infected stones should suggest that urinary tract infection could change the urine chemistry in a lithogenic direction and be only cause of stone formation.
54例感染性肾结石患者接受了全面的代谢评估，以寻找导致结石形成的潜在因素，包括尿液分析和培养。混合感染结石（鸟粪石±磷灰石和草酸钙）患者的代谢异常明显多于单纯感染结石（鸟粪石±碳酸磷灰石）患者：高钙尿症占40%，高草酸尿症占34%，高尿酸尿症占28%（p<0.05）。两组患者的枸橼酸盐尿排泄均较低，无统计学显著差异（238±117mg/24小时 vs 214±104mg/24小时，t=0.72，p=0.5）。单纯感染结石患者中存在的少数代谢异常表明，尿路感染可能会使尿液化学性质朝着致石方向改变，并且可能是结石形成的唯一原因。
