Munukka M, Waller B, Multanen J, Rantalainen T, Häkkinen A, Nieminen M T, Lammentausta E, Kujala U M, Paloneva J, Kautiainen H, Kiviranta I, Heinonen A
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
J Musculoskelet Neuronal Interact. 2014 Dec;14(4):418-24.
To investigate whether neuromuscular performance predicts lower limb bone strength in different lower limb sites in postmenopausal women with mild knee osteoarthritis (OA).
Neuromuscular performance of 139 volunteer women aged 50-68 with mild knee OA was measured using maximal counter movement jump test, isometric knee flexion and extension force and figure-of-eight-running test. Femoral neck section modulus (Z, mm(3)) was determined by data obtained from dual-energy X-ray absorptiometry. Data obtained using peripheral quantitative computed tomography was used to asses distal tibia compressive (BSId, g(2)/cm(4)) and tibial mid-shaft bending (SSImax(mid), mm(3)) strength indices.
After adjustment for height, weight and age, counter movement jump peak power production was the strongest independent predictor for Z (β=0.44; p<0.001) and for BSId (β=0.32; p=0.003). This was also true in concentric net impulse for Z (β=0.37; p=0.001) and for BSId (β=0.40; p<0.001). Additionally, knee extension force (β=0.30; p<0.001) and figure-of-eight-running test (β= -0.32; p<0.001) were among strongest independent predictors for BSId after adjustments. For SSImax(mid), concentric net impulse (β=0.33; p=0.002) remained as the strongest independent predictor after adjustments.
Neuromuscular performance in postmenopausal women with mild knee OA predicted lower limb bone strength in every measured skeletal site.
研究在患有轻度膝关节骨关节炎（OA）的绝经后女性中，神经肌肉功能是否能预测不同下肢部位的下肢骨强度。
对139名年龄在50 - 68岁、患有轻度膝关节OA的志愿者女性进行神经肌肉功能测试，采用最大反向运动跳跃测试、等长膝关节屈伸力量测试和“8”字跑测试。通过双能X线吸收法获得的数据确定股骨颈截面模量（Z，mm³）。使用外周定量计算机断层扫描获得的数据用于评估胫骨远端压缩强度指数（BSId，g²/cm⁴）和胫骨中段弯曲强度指数（SSImax(mid)，mm³）。
在调整身高、体重和年龄后，反向运动跳跃峰值功率输出是Z（β = 0.44；p < 0.001）和BSId（β = 0.32；p = 0.003）的最强独立预测因素。对于Z（β = 0.37；p = 0.001）和BSId（β = 0.40；p < 0.001），向心净冲量也是如此。此外，调整后，膝关节伸展力（β = 0.30；p < 0.001）和“8”字跑测试（β = -0.32；p < 0.001）是BSId的最强独立预测因素之一。对于SSImax(mid)，调整后向心净冲量（β = 0.33；p = 0.002）仍然是最强的独立预测因素。
患有轻度膝关节OA的绝经后女性的神经肌肉功能可预测每个测量骨骼部位的下肢骨强度。
