Miller Craig A, Durham Amy C, Schaffer Paula A, Ehrhart E J, Powers Barb E, Duncan Colleen G
Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO (Miller, Schaffer, Ehrhart, Powers, Duncan)Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA (Durham)
Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO (Miller, Schaffer, Ehrhart, Powers, Duncan)Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA (Durham).
J Vet Diagn Invest. 2015 Jan;27(1):86-91. doi: 10.1177/1040638714561653.
Equine cutaneous lymphoma is an uncommon disease that can present with variable clinical signs, immunosuppression, and rapid systemic disease progression. Various subtypes of equine lymphoma have been described and classified according to a veterinary adaptation of the World Health Organization classification system, but little data is available regarding the association between lymphoma subtypes and epidemiological criteria and/or clinical outcome. The objective of the current study was to classify previously diagnosed cases of equine cutaneous lymphoma and correlate subtypes with clinical data to investigate epidemiological trends and prognostic implications. Results from the study confirm T-cell-rich, large B-cell lymphoma (TCRLBCL) as the predominant subtype in equine cutaneous lymphoma. Cutaneous T-cell lymphoma (CTCL) was the second most common phenotype in the current study. To the authors' knowledge, a description of the morphological and immunohistochemical features of CTCL in horses, an epitheliotropic neoplasm similar to the cutaneous epitheliotropic lymphoma variant (mycosis fungoides) observed in human beings and canids, has not been previously described. Less common lymphoma subtypes identified in the study include diffuse large B-cell lymphoma and anaplastic large T-cell lymphoma. Quarter Horses almost exclusively developed TCRLBCL, while the frequency of CTCL was increased significantly in Thoroughbreds compared with other breeds. TCRLBCLs more frequently presented as multiple masses while CTCLs were more often solitary nodules. When multiple regions of the body were affected, 100% of cases were TCRBCL. Finally, there was an observable trend for longer survival in cases of TCRLBCL without local recurrence, suggesting adequate surgical excision may be an effective treatment modality.
马皮肤淋巴瘤是一种罕见疾病，可表现出多种临床症状、免疫抑制及快速的全身疾病进展。根据世界卫生组织分类系统的兽医适应性版本，已对马淋巴瘤的各种亚型进行了描述和分类，但关于淋巴瘤亚型与流行病学标准和/或临床结果之间的关联，可用数据很少。本研究的目的是对先前诊断的马皮肤淋巴瘤病例进行分类，并将亚型与临床数据相关联，以调查流行病学趋势和预后影响。该研究结果证实，富含T细胞的大B细胞淋巴瘤（TCRLBCL）是马皮肤淋巴瘤的主要亚型。皮肤T细胞淋巴瘤（CTCL）是本研究中第二常见的表型。据作者所知，此前尚未描述过马CTCL的形态学和免疫组化特征，它是一种亲表皮性肿瘤，类似于在人类和犬类中观察到的皮肤亲表皮性淋巴瘤变体（蕈样肉芽肿）。该研究中鉴定出的较不常见的淋巴瘤亚型包括弥漫性大B细胞淋巴瘤和间变性大T细胞淋巴瘤。四分之一马几乎只发生TCRLBCL，而与其他品种相比，纯种马中CTCL的发生率显著增加。TCRLBCL更常表现为多个肿块，而CTCL更常为单个结节。当身体多个部位受累时，100%的病例为TCRBCL。最后，在无局部复发的TCRLBCL病例中，存在生存时间较长的可观察趋势，提示充分的手术切除可能是一种有效的治疗方式。
