Skoch Jesse, Kobylanski Kelly, Rice Jeffrey M, Baaj Ali A
Department of Surgery, Division of Neurological Surgery, The University of Arizona Medical Center, Tucson, Arizona, USA.
Department of Pathology, The University of Arizona Medical Center, Tucson, Arizona, USA.
Surg Neurol Int. 2014 Nov 21;5:161. doi: 10.4103/2152-7806.145205. eCollection 2014.
There are few cases of choriocarcinoma metastases to the spine that have been reported. Most occurrences are in women with the gestational form of the tumor, and these now exhibit a very high remission rate with chemotherapeutic treatment, typically circumventing the need for spinal surgery.
In an effort to better understand treatment options for those rare instances when choriocarcinoma does find its way into the spine, we have synthesized a comprehensive literature review on the clinical cases of choriocarcinoma spinal metastases. We also describe our unique experience and decision-making involving the first reported case of surgical treatment of non-gestational choriocarcinoma spinal metastases in a male patient.
Spinal surgery has a limited role in metastatic choriocarcinoma, but there is the potential for improving neurologic decline even in the rare and aggressive male variant of this disease.
据报道,绒毛膜癌转移至脊柱的病例很少。大多数病例发生在患有妊娠性绒毛膜癌的女性中,目前这些病例通过化疗治疗显示出非常高的缓解率,通常无需进行脊柱手术。
为了更好地了解绒毛膜癌转移至脊柱这种罕见情况的治疗选择,我们综合回顾了绒毛膜癌脊柱转移的临床病例文献。我们还描述了我们在一名男性患者中首次报道的非妊娠性绒毛膜癌脊柱转移手术治疗的独特经验和决策过程。
脊柱手术在转移性绒毛膜癌中的作用有限,但即使在这种疾病罕见且侵袭性强的男性病例中,也有可能改善神经功能衰退。