Environ Sci Technol. 2015 Jan 20;49(2):785-91. doi: 10.1021/es503748w.
Polychlorinated biphenyls (PCBs) and enantiomer fractions (EFs) of PCB enantiomers (PCBs 95, 132, 135, and 149) were investigated in soil and chicken feed, chicken (Gallus domesticus) tissues, eggs on 0, 7, and 14 days after the onset of incubation, and newborn chick tissues. The EF values of PCBs 95, 132, and 149 changed significantly from soil to chicken tissues, and the values in the liver exhibited the highest deviation from the racemic ratio, indicating enantiomer-selective metabolism in hens. Congeners, which are highly resistant to degradation, such as PCBs 138, 153, and 180, exhibited the highest maternal transfer potentials when muscle and liver were used to assess the maternal transfer. However, uniform transfer ratios were observed for most of the PCB congeners when visceral fat was used. The EFs of chiral PCBs in eggs either did not match with muscle or with liver or were similar to those in visceral fat. These results indicate that hens mainly mobilized visceral fat for egg formation and PCBs were deposited in eggs by associating with these lipid materials. Further enantiomeric enrichment of PCBs 95, 132, and 149 occurred in the newborn chick tissues. However, an opposite enantioselectivity for PCB 135 in newborn chicks was observed. These results indicate that the potential toxicity of PCB enantiomers to newborn chicks may be different from that of adults.
多氯联苯（PCBs）和对映体分数（EFs）的对映体 PCBs（95、132、135 和 149）在土壤和鸡饲料、鸡（Gallus domesticus）组织、孵化后 0、7 和 14 天的鸡蛋以及新生鸡组织中进行了研究。PCBs 95、132 和 149 的 EF 值从土壤到鸡组织发生了显著变化，肝脏中的值与外消旋比例偏差最大，表明母鸡中存在对映体选择性代谢。高抗降解的同系物，如 PCBs 138、153 和 180，当肌肉和肝脏用于评估母体转移时，表现出最高的母体转移潜力。然而，当使用内脏脂肪时，大多数 PCB 同系物的转移比均匀。鸡蛋中手性 PCB 的 EF 与肌肉或肝脏不匹配，或者与内脏脂肪相似。这些结果表明，母鸡主要动员内脏脂肪来形成鸡蛋，PCBs 通过与这些脂质材料结合而沉积在鸡蛋中。在新生鸡组织中，PCBs 95、132 和 149 进一步发生对映体富集。然而，在新生小鸡中观察到 PCB 135 的对映选择性相反。这些结果表明，PCB 对映体对新生小鸡的潜在毒性可能与对成年鸡的毒性不同。
