Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg and German Center for Infection Research, 69120 Heidelberg, Germany; Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy.
Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy.
Cell Host Microbe. 2014 Nov 12;16(5):557-9. doi: 10.1016/j.chom.2014.10.012.
Productive HIV-1 infection requires viral cDNA integration into the host genome, an event catalyzed by HIV-1 integrase. In this issue of Cell Host & Microbe, Demeulemeester et al. (2014) report the existence of natural integrase polymorphisms that retarget viral integration away from gene-dense regions and are associated with rapid disease progression.
有效的 HIV-1 感染需要病毒 cDNA 整合到宿主基因组中，这一过程由 HIV-1 整合酶催化。在本期《细胞宿主与微生物》中，Demeulemeester 等人（2014）报道了自然存在的整合酶多态性，这些多态性将病毒整合重新定向到基因密度较低的区域，与疾病快速进展相关。
