抗癌药与抗寄生虫药的相互作用：是否存在共同靶点？

Mutual action of anticancer and antiparasitic drugs: are there any shared targets?

作者信息

Dorosti Zahra, Yousefi Morteza, Sharafi Seyedeh Maryam, Darani Hossein Yousofi

机构信息

Department of Parasitology & Mycology, Faculty of Medicine, Isfahan University of Medical sciences, Isfahan, Iran.

出版信息

Future Oncol. 2014 Dec;10(15):2529-39. doi: 10.2217/fon.14.65.

DOI:10.2217/fon.14.65

PMID:25525859

Abstract

Parasites and cancers have some common features. It has been shown that some parasites interfere with tumor growth. In addition, they both have common antigens such as the Tn antigen. A communal action of anticancer and antiparasitic drugs has been reported. This shared action may be related to common targets for these drugs in cancers and parasites. In this paper, mutual action of anticancer and antiparasitic drugs, with the aim of discussing shared targets of these drugs, has been reviewed.

摘要

寄生虫和癌症有一些共同特征。研究表明，一些寄生虫会干扰肿瘤生长。此外，它们都有共同的抗原，如Tn抗原。已有报道称抗癌药和抗寄生虫药存在共同作用。这种共同作用可能与这些药物在癌症和寄生虫中的共同靶点有关。本文综述了抗癌药和抗寄生虫药的相互作用，旨在探讨这些药物的共同靶点。