Gambino Dinorah, Otero Lucía
Área Química Inorgánica, DEC, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Front Chem. 2022 Jan 7;9:816266. doi: 10.3389/fchem.2021.816266. eCollection 2021.
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis (CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites belonging to the kinetoplastid order and they constitute an urgent global health problem. In fact, there is an urgent need of more efficient and less toxic chemotherapy for these diseases. Medicinal inorganic chemistry currently offers an attractive option for the rational design of new drugs and, in particular, antiparasitic ones. In this sense, one of the main strategies for the design of metal-based antiparasitic compounds has been the coordination of an organic ligand with known or potential biological activity, to a metal centre or an organometallic . Classical metal coordination complexes or organometallic compounds could be designed as multifunctional agents joining, in a single molecule, different chemical species that could affect different parasitic targets. This review is focused on the rational design of palladium(II) and platinum(II) compounds with bioactive ligands as prospective drugs against trypanosomatid parasites that has been conducted by our group during the last 20 years.
人类非洲锥虫病（HAT）、恰加斯病或美洲锥虫病（CD）以及利什曼病是由属于动质体目的锥虫寄生虫引起的原生动物感染，它们构成了一个紧迫的全球健康问题。事实上，迫切需要针对这些疾病开发更高效、毒性更低的化疗方法。药用无机化学目前为合理设计新药，特别是抗寄生虫药物提供了一个有吸引力的选择。从这个意义上讲，设计基于金属的抗寄生虫化合物的主要策略之一是将具有已知或潜在生物活性的有机配体与金属中心或有机金属配位。经典的金属配位络合物或有机金属化合物可以设计为多功能试剂，在单个分子中结合不同的化学物种，这些物种可能作用于不同的寄生虫靶点。本综述聚焦于我们团队在过去20年中对具有生物活性配体的钯（II）和铂（II）化合物进行合理设计，作为对抗锥虫寄生虫的潜在药物的研究。
