Thériault G P, Tremblay C G, Armstrong B G
School of Occupational Health, McGill University, Montreal, Canada.
J Occup Med. 1990 Sep;32(9):869-72. doi: 10.1097/00043764-199009000-00021.
We evaluated a cytology screening program, offered by a large aluminum producer after the discovery of an excess of bladder cancer due to occupational exposure to coal-tar-pitch volatiles, in terms of early detection and survival, based on information in the public domain. From January 1970 through June 1986, 79 cases of bladder cancer were identified in this cohort of aluminum workers aged 65 years or younger. By the end of 1986, 36 had died, with bladder cancer as the primary cause of death for 53%. Cases diagnosed after the screening program was introduced in 1980 were compared with those diagnosed earlier. In cases diagnosed after 1980, the proportion identified at early stages was higher (77% v 67%) and survival seemed improved but the differences were not statistically significant. Although these results do not encourage an optimistic view of screening effectiveness in this population, the limits inherent in the present study make it impossible to draw any firm conclusion. Studies restricted to public domain information do not appear to have sufficient data to evaluate workplace screening programs.
我们根据公开资料，对一家大型铝生产商在发现因职业接触煤焦油沥青挥发物导致膀胱癌超标后提供的细胞学筛查计划进行了早期检测和生存方面的评估。从1970年1月到1986年6月，在这个65岁及以下的铝工人群体中，共确诊了79例膀胱癌。到1986年底，36人死亡，其中53%的人死于膀胱癌。将1980年引入筛查计划后确诊的病例与早期确诊的病例进行了比较。在1980年后确诊的病例中，早期发现的比例更高（77%对67%），生存情况似乎有所改善，但差异无统计学意义。尽管这些结果不支持对该人群筛查效果持乐观态度，但本研究固有的局限性使得无法得出任何确凿结论。限于公开资料的研究似乎没有足够的数据来评估工作场所的筛查计划。
