3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?
作者信息
Hernandez Arturo
机构信息
Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074.
出版信息
Endocrinology. 2015 Jan;156(1):5-7. doi: 10.1210/en.2014-1933.
Abstract
摘要
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1
3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?膳食补充剂中的3,5-二碘-L-甲状腺原氨酸（T2）：其生理作用有哪些？
Endocrinology. 2015 Jan;156(1):5-7. doi: 10.1210/en.2014-1933.
2
3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice.3,5-二碘-L-甲状腺素（3,5-t2）对雄性饮食诱导肥胖小鼠的下丘脑-垂体-甲状腺轴、身体成分和能量代谢发挥甲状腺刺激作用。
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Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine.3,5-二碘-L-甲状腺原氨酸和3,3'-二碘-L-甲状腺原氨酸在体外对大鼠肝脏细胞色素氧化酶活性的快速刺激作用。
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3,5-T2 alters murine genes relevant for xenobiotic, steroid, and thyroid hormone metabolism.3,5-二碘甲状腺原氨酸改变与异生物、类固醇和甲状腺激素代谢相关的小鼠基因。
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Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats stimulates bioenergetic parameters in liver mitochondria.对甲状腺功能减退的大鼠急性给予3,5-二碘-L-甲状腺原氨酸可刺激肝线粒体中的生物能量参数。
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Calorigenic effect of diiodothyronines in the rat.二碘甲状腺原氨酸对大鼠的产热作用。
J Physiol. 1996 Aug 1;494 ( Pt 3)(Pt 3):831-7. doi: 10.1113/jphysiol.1996.sp021536.
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Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats affects bioenergetic parameters in rat skeletal muscle mitochondria.对甲状腺功能减退的大鼠急性给予3,5-二碘-L-甲状腺原氨酸会影响大鼠骨骼肌线粒体中的生物能量参数。
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本文引用的文献
1
3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice.3,5-二碘-L-甲状腺素（3,5-t2）对雄性饮食诱导肥胖小鼠的下丘脑-垂体-甲状腺轴、身体成分和能量代谢发挥甲状腺刺激作用。
Endocrinology. 2015 Jan;156(1):389-99. doi: 10.1210/en.2014-1604.
2
Thyroid hormone regulation of metabolism.甲状腺激素对代谢的调节。
Physiol Rev. 2014 Apr;94(2):355-82. doi: 10.1152/physrev.00030.2013.
3
Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues.三碘甲状腺原氨酸（T3）的给药会导致中枢性甲状腺功能减退，并刺激甲状腺敏感组织。
J Endocrinol. 2014 Jun;221(3):415-27. doi: 10.1530/JOE-13-0502. Epub 2014 Apr 1.
4
Thyroid hormone, thyromimetics, and metabolic efficiency.甲状腺激素、甲状腺刺激素和代谢效率。
Endocr Rev. 2014 Feb;35(1):35-58. doi: 10.1210/er.2013-1006. Epub 2013 Dec 4.
5
3,5-T2 is an alternative ligand for the thyroid hormone receptor β1.3,5-二碘甲状腺原氨酸（T2）是甲状腺激素受体β1 的替代配体。
Endocrinology. 2013 Aug;154(8):2948-58. doi: 10.1210/en.2013-1030. Epub 2013 Jun 4.
6
Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-L-thyronine in rats.3,5-二碘-L-甲状腺素预防大鼠饮食诱导的胰岛素抵抗非甲状腺毒性。
Diabetes. 2011 Nov;60(11):2730-9. doi: 10.2337/db11-0207. Epub 2011 Sep 16.
7
Thyroid hormones, mitochondrial bioenergetics and lipid handling.甲状腺激素、线粒体生物能学和脂质处理。
Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):402-7. doi: 10.1097/MED.0b013e32833cf354.
8
TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet.TRC150094 是一种新型甲状腺激素功能类似物，可通过增加高脂肪饮食大鼠的能量消耗和脂肪酸氧化来减少肥胖。
FASEB J. 2010 Sep;24(9):3451-61. doi: 10.1096/fj.10-157115. Epub 2010 May 7.
9
Metabolic effects of thyroid hormone derivatives.甲状腺激素衍生物的代谢效应。
Thyroid. 2008 Feb;18(2):239-53. doi: 10.1089/thy.2007.0248.
10
Selective modulation of thyroid hormone receptor action.甲状腺激素受体作用的选择性调节
J Steroid Biochem Mol Biol. 2001 Jan-Mar;76(1-5):31-42. doi: 10.1016/s0960-0760(01)00052-8.
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