Leung Chris Wai Tung, Guo Feng, Hong Yuning, Zhao Engui, Kwok Ryan Tsz Kin, Leung Nelson Lik Ching, Chen Sijie, Vaikath Nishant N, El-Agnaf Omar Mukhtar, Tang Youhong, Gai Wei-Ping, Tang Ben Zhong
HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park Nanshan, Shenzhen 518057, China.
Chem Commun (Camb). 2015 Feb 4;51(10):1866-9. doi: 10.1039/c4cc07911f.
We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.
