Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence.
作者信息
Leung Chris Wai Tung, Guo Feng, Hong Yuning, Zhao Engui, Kwok Ryan Tsz Kin, Leung Nelson Lik Ching, Chen Sijie, Vaikath Nishant N, El-Agnaf Omar Mukhtar, Tang Youhong, Gai Wei-Ping, Tang Ben Zhong
机构信息
HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park Nanshan, Shenzhen 518057, China.
出版信息
Chem Commun (Camb). 2015 Feb 4;51(10):1866-9. doi: 10.1039/c4cc07911f.
We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.
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