Strand Cosmetics Europe, 124 route du Charpenay, 69210 Lentilly, France; Laboratoire d'Automatique et de Génie des Procédés (LAGEP) CNRS UMR5007, Université de Lyon, Université Lyon 1, Villeurbanne, F-69622 Lyon, France.
Laboratoire d'Automatique et de Génie des Procédés (LAGEP) CNRS UMR5007, Université de Lyon, Université Lyon 1, Villeurbanne, F-69622 Lyon, France.
Int J Pharm. 2015 Feb 1;479(1):88-95. doi: 10.1016/j.ijpharm.2014.12.031. Epub 2014 Dec 16.
Zinc oxide (ZnO) appears as a promising preservative for pharmaceutical or cosmetic formulations. The other ingredients of the formulations may have specific interactions with ZnO that alter its antimicrobial properties. The influence of common formulation excipients on the antimicrobial efficacy of ZnO has been investigated in simple model systems and in typical topical products containing a complex formulation. A wide variety of formulation excipients have been investigated for their interactions with ZnO: antioxidants, chelating agents, electrolytes, titanium dioxide pigment. The antimicrobial activity of ZnO against Escherichia coli was partially inhibited by NaCl and MgSO4 salts. A synergistic influence of uncoated titanium dioxide has been observed. The interference effects of antioxidants and chelating agents were quite specific. The interactions of these substances with ZnO particles and with the soluble species released by ZnO were discussed so as to reach scientific guidelines for the choice of the ingredients. The preservative efficacy of ZnO was assessed by challenge testing in three different formulations: an oil-in-water emulsion; a water-in-oil emulsion and a dry powder. The addition of ZnO in complex formulations significantly improved the microbiological quality of the products, in spite of the presence of other ingredients that modulate the antimicrobial activity.
氧化锌（ZnO）作为一种有前途的药物或化妆品制剂的防腐剂。制剂的其他成分可能与 ZnO 发生特定的相互作用，从而改变其抗菌性能。已经在简单的模型系统中和含有复杂制剂的典型局部用产品中研究了常见制剂赋形剂对 ZnO 抗菌功效的影响。已经研究了多种制剂赋形剂与 ZnO 的相互作用：抗氧化剂、螯合剂、电解质、二氧化钛颜料。NaCl 和 MgSO4 盐部分抑制了 ZnO 对大肠杆菌的抗菌活性。观察到未涂覆的二氧化钛具有协同作用。抗氧化剂和螯合剂的干扰作用具有很强的特异性。讨论了这些物质与 ZnO 颗粒以及 ZnO 释放的可溶性物质的相互作用，以便为选择成分提供科学指导。通过在三种不同制剂（油包水乳液；水包油乳液和干粉）中的挑战性测试评估了 ZnO 的防腐功效。尽管存在其他调节抗菌活性的成分，但在复杂制剂中添加 ZnO 可显著提高产品的微生物质量。
