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生物源氧化锌纳米颗粒及其生物医学应用综述

Biogenic Zinc Oxide Nanoparticles and Their Biomedical Applications: A Review.

作者信息

Jha Shruti, Rani Ritu, Singh Sandeep

机构信息

Department of Biochemistry, M.D. University, Rohtak, 124001 India.

出版信息

J Inorg Organomet Polym Mater. 2023 Apr 20:1-16. doi: 10.1007/s10904-023-02550-x.

Abstract

Nanotechnology has inscribed novel perception into the material science and one of the most extensively used nanomaterials is Zinc oxide nanoparticles (ZnO NPs) with healthcare and biomedical applications. Because of its outstanding biocompatibility, low toxicity, and low cost, ZnO NPs have become one of the most prominent metal oxide NPs in biological applications. This review highlights the different aspects of ZnO NPs, like their green synthesis as a substitute of conventional route due to avoidance of threat of hazardous, costly precursors and subsequent mostly therapeutic applications. Due to their wide bandwidth and high excitation binding energy, ZnO NPs have undergone extensive research. In addition to their potential applications as antibiotics, antioxidants, anti-diabetics, and cytotoxic agents, ZnO NPs also hold a promising future as an antiviral treatment for SARS-CoV-2. Zn has antiviral properties and may be effective against a variety of respiratory virus species, particularly SARS-CoV-2. This review includes a variety of topics, including the virus's structural properties, an overview of infection mechanism, and current COVID-19 treatments. Nanotechnology-based techniques for the prevention, diagnosis, and treatment of COVID-19 are also discussed in this review.

摘要

纳米技术为材料科学带来了全新的认识,而应用于医疗保健和生物医学领域的氧化锌纳米颗粒(ZnO NPs)是使用最为广泛的纳米材料之一。由于其出色的生物相容性、低毒性和低成本,ZnO NPs已成为生物应用中最突出的金属氧化物纳米颗粒之一。本综述重点介绍了ZnO NPs的不同方面,例如其绿色合成方法,作为传统方法的替代方案,可避免使用危险、昂贵的前体带来的威胁,以及随后的主要治疗应用。由于其宽带隙和高激发结合能,ZnO NPs已得到广泛研究。除了作为抗生素、抗氧化剂、抗糖尿病药物和细胞毒性剂的潜在应用外,ZnO NPs作为针对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的抗病毒治疗方法也具有广阔前景。锌具有抗病毒特性,可能对多种呼吸道病毒有效,尤其是SARS-CoV-2。本综述涵盖了多个主题,包括病毒的结构特性、感染机制概述以及当前针对2019冠状病毒病(COVID-19)的治疗方法。本综述还讨论了基于纳米技术的COVID-19预防、诊断和治疗技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f6/10118236/4da662bb4a81/10904_2023_2550_Fig1_HTML.jpg

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