异氟烷诱导的低血压麻醉对大脑的不良影响。

Adverse effects on the brain in connection with isoflurane-induced hypotensive anaesthesia.

作者信息

Enlund M, Ahlstedt B, Revenäs B, Krekmanov L, Ronquist G

机构信息

Department of Anesthesia, Central Hospital, Västerås, Sweden.

出版信息

Acta Anaesthesiol Scand. 1989 Jul;33(5):413-5. doi: 10.1111/j.1399-6576.1989.tb02935.x.

DOI:10.1111/j.1399-6576.1989.tb02935.x

PMID:2552735

Abstract

As a marker of brain cell injury, adenylate kinase (AK) was measured in cerebrospinal fluid (CSF) in 10 patients given anaesthesia with isoflurane-induced hypotension for corrective surgery of dentofacial deformities. Nine out of 10 patients displayed a marked increase in CSF-AK postoperatively compared with preoperative values. The postoperative mean value displayed a 400% increase compared to the corresponding preoperative value. This difference was statistically significant (P = 0.001). The rise in CSF-AK was most probably the result of an enhanced efflux of AK into CSF subsequent to a presumed hypoxic injury to brain cells.

摘要

作为脑细胞损伤的标志物，对10例因牙颌面畸形矫正手术接受异氟烷诱导低血压麻醉的患者的脑脊液（CSF）中的腺苷酸激酶（AK）进行了测量。10例患者中有9例术后脑脊液AK值与术前相比显著升高。术后平均值与相应术前值相比增加了400%。这种差异具有统计学意义（P = 0.001）。脑脊液AK升高很可能是由于假定的脑细胞缺氧损伤后AK向脑脊液的外流增加所致。