Mann Stephanie E, Maille Nicole, Clas Darren, Osol George
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA.
Reprod Sci. 2015 Jul;22(7):802-7. doi: 10.1177/1933719114561556. Epub 2014 Dec 18.
Perivascular adipose tissue (PVAT) contributes to vasoregulation. The role of this adipose tissue bed in pregnancy has not been examined. Here, we tested the hypothesis that PVAT in pregnant rats decreases resistance artery tone. Mesenteric arteries from nonpregnant (NP) and late pregnant (LP) rats were exposed to phenylephrine (PHE) or KCl in the presence (+) versus absence (-) of PVAT. The LP PVAT(+) vessels showed a 44% decrease in sensitivity to PHE in the presence of PVAT. There was no attenuation of the contractile response to KCl when PVAT was present. The LP arteries perfused with LP or NP PVAT underwent vasodilation; unexpectedly, NP vessels in the presence of PVAT from LP rats sustained a 48% vasoconstriction. The PVAT attenuates vasoconstriction by a mechanism that involves hyperpolarization. The vasoconstriction observed when nonpregnant vessels were exposed to pregnant PVAT suggests pregnant vessels adapt to the vasoconstricting influence of pregnant PVAT.
血管周围脂肪组织（PVAT）参与血管调节。目前尚未研究该脂肪组织床在妊娠中的作用。在此，我们检验了一个假设，即妊娠大鼠的PVAT会降低阻力动脉张力。将未妊娠（NP）和妊娠晚期（LP）大鼠的肠系膜动脉在有（+）或无（-）PVAT的情况下暴露于去氧肾上腺素（PHE）或氯化钾（KCl）。在有PVAT存在的情况下，LP组PVAT（+）血管对PHE的敏感性降低了44%。当存在PVAT时，对KCl的收缩反应没有减弱。用LP或NP的PVAT灌注的LP动脉出现血管舒张；出乎意料的是，在存在来自LP大鼠的PVAT的情况下，NP血管持续出现48%的血管收缩。PVAT通过一种涉及超极化的机制减弱血管收缩。当未妊娠血管暴露于妊娠PVAT时观察到的血管收缩表明，妊娠血管适应了妊娠PVAT的血管收缩影响。
