肿瘤血管和神经胶质瘤干细胞：对神经胶质瘤进展的贡献。

Tumor vasculature and glioma stem cells: Contributions to glioma progression.

机构信息

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

出版信息

Cancer Lett. 2016 Oct 1;380(2):545-551. doi: 10.1016/j.canlet.2014.12.028. Epub 2014 Dec 16.

DOI:10.1016/j.canlet.2014.12.028

PMID:25527451

Abstract

Glioblastoma multiforme (GBM), the most malignant of brain tumors, is characterized by extensive vascularization and a high degree of invasion. The current standard of care is not very effective, resulting in tumor recurrence with patients rarely surviving over 2 years. This tumor recurrence is attributed to the presence of chemo and radiation resistant glioma stem cells (GSCs). These cells are associated with vascular niches which regulate GSC self-renewal and survival. Recent studies suggest that while blood vessels support glioma stem cells, these tumor cells in turn may regulate and contribute to the tumor vasculature by transdifferentiating into endothelial cells directly or through the secretion of regulatory growth factors such as vascular endothelial growth factor (VEGF) and hepatoma derived growth factor (HDGF). The relationship between the tumor vasculature and the glioma stem cells is the subject of this review.

摘要

多形性胶质母细胞瘤（GBM）是最恶性的脑肿瘤，其特征为广泛的血管生成和高度侵袭性。目前的治疗标准效果不佳，导致肿瘤复发，患者很少能存活超过 2 年。这种肿瘤复发归因于存在化疗和放疗耐药的神经胶质瘤干细胞（GSCs）。这些细胞与血管壁龛有关，这些血管壁龛调节 GSC 的自我更新和存活。最近的研究表明，虽然血管支持神经胶质瘤干细胞，但这些肿瘤细胞反过来可能通过直接转分化为内皮细胞或通过分泌调节生长因子如血管内皮生长因子（VEGF）和肝癌衍生生长因子（HDGF），来调节和促进肿瘤血管生成。本综述的主题是肿瘤血管生成与神经胶质瘤干细胞之间的关系。