粒细胞-巨噬细胞集落刺激因子（GM-CSF）与调理作用协同增强人中性粒细胞吞噬作用诱导的白三烯B4（LTB4）合成。
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4 (LTB4) synthesis induced by phagocytosis in human neutrophils.
作者信息
Poubelle P E, Bourgoin S, Naccache P H, Borgeat P
机构信息
Unité de Recherche Inflammation et Immunologie-Rhumatologie, Centre de Recherche du CHUL, Qué, Canada.
出版信息
Agents Actions. 1989 Jun;27(3-4):388-90. doi: 10.1007/BF01972830.
Normal human blood neutrophils were studied for their capacity to synthesize leukotriene B4 (LTB4) and its omega-oxidized metabolites after phagocytosis of zymosan. Phagocytosis of serum-opsonized particles led to a higher release of LTs than did unopsonized zymosan. The most striking effect of phagocytosis was observed when neutrophils were primed with granulocyte-macrophage colony-stimulating factor (GM-CSF): opsonization and GM-CSF synergistically increased LTB4 synthesis by neutrophils.
对正常人血液中的中性粒细胞进行研究，以观察其在吞噬酵母聚糖后合成白三烯B4（LTB4）及其ω-氧化代谢产物的能力。与未调理的酵母聚糖相比，血清调理颗粒的吞噬作用导致白三烯的释放量更高。当中性粒细胞用粒细胞-巨噬细胞集落刺激因子（GM-CSF）进行预处理时，观察到吞噬作用最显著的效果：调理作用和GM-CSF协同增加中性粒细胞合成LTB4的能力。
Zotero 插件