Ito Shinya
J Popul Ther Clin Pharmacol. 2014;21(3):e565-8. Epub 2014 Dec 11.
Medications taken for chronic illness (e.g., depression, epilepsy, immunological conditions) while breastfeeding pose challenges to risk-assessment. Based on several cases of drug toxicity (or lack thereof) in the breastfeeding infant, individual risk:benefit analyses are discussed. The benefits of human milk are highlighted, together with clinically important principles for patient management, the spectrum of adverse effects in the infant, and emerging concerns regarding the safety of some medications during breastfeeding. A practical guide for patient management is presented.
母乳喂养期间服用治疗慢性病的药物(如治疗抑郁症、癫痫、免疫性疾病的药物)给风险评估带来了挑战。基于母乳喂养婴儿中几例药物毒性(或无毒性)的病例,讨论了个体的风险效益分析。强调了母乳的益处,以及患者管理的重要临床原则、婴儿的不良反应范围,以及母乳喂养期间某些药物安全性方面新出现的问题。还提供了一份患者管理实用指南。