Dipnall Joanna F, Pasco Julie A, Meyer Denny, Berk Michael, Williams Lana J, Dodd Seetal, Jacka Felice N
IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, Australia; Department of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Hawthorn, VIC, Australia.
IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, Australia; NorthWest Academic Centre, Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia.
J Affect Disord. 2015 Mar 15;174:215-24. doi: 10.1016/j.jad.2014.11.030. Epub 2014 Nov 27.
Type 2 diabetes and depression are commonly comorbid high-prevalence chronic disorders. Diet is a key diabetes risk factor and recent research has highlighted the relevance of diet as a possible risk for factor common mental disorders. This study aimed to investigate the interrelationship among dietary patterns, diabetes and depression.
Data were integrated from the National Health and Nutrition Examination Study (2009-2010) for adults aged 18+ (n=4588, Mean age=43yr). Depressive symptoms were measured by the Patient Health Questionnaire-9 and diabetes status determined via self-report, usage of diabetic medication and/or fasting glucose levels ≥126mg/dL and a glycated hemoglobin level ≥6.5% (48mmol/mol). A 24-h dietary recall interview was given to determine intakes. Multiple logistic regression was employed, with depression the outcome, and dietary patterns and diabetes the predictors. Covariates included gender, age, marital status, education, race, adult food insecurity level, ratio of family income to poverty, and serum C-reactive protein.
Exploratory factor analysis revealed five dietary patterns (healthy; unhealthy; sweets; 'Mexican' style; breakfast) explaining 39.8% of the total variance. The healthy dietary pattern was associated with reduced odds of depression for those with diabetes (OR 0.68, 95% CI [0.52, 0.88], p=0.006) and those without diabetes (OR 0.79, 95% CI [0.64, 0.97], p=0.029) (interaction p=0.048). The relationship between the sweets dietary pattern and depression was fully explained by diabetes status.
In this study, a healthy dietary pattern was associated with a reduced likelihood of depressive symptoms, especially for those with Type 2 diabetes.
2型糖尿病和抑郁症是常见的共病高发慢性疾病。饮食是糖尿病的一个关键风险因素，最近的研究强调了饮食作为常见精神障碍可能风险因素的相关性。本研究旨在探讨饮食模式、糖尿病和抑郁症之间的相互关系。
整合了美国国家健康与营养检查调查（2009 - 2010年）中18岁及以上成年人的数据（n = 4588，平均年龄 = 43岁）。通过患者健康问卷-9测量抑郁症状，通过自我报告、糖尿病药物使用情况和/或空腹血糖水平≥126mg/dL以及糖化血红蛋白水平≥6.5%（48mmol/mol）来确定糖尿病状态。进行24小时饮食回顾访谈以确定摄入量。采用多元逻辑回归，以抑郁症为结果变量，饮食模式和糖尿病为预测变量。协变量包括性别、年龄、婚姻状况、教育程度、种族、成人粮食不安全水平、家庭收入与贫困比率以及血清C反应蛋白。
探索性因素分析揭示了五种饮食模式（健康型；不健康型；甜食型；“墨西哥”风格型；早餐型），解释了总方差的39.8%。健康饮食模式与糖尿病患者（比值比0.68，95%置信区间[0.52, 0.88]，p = 0.006）和非糖尿病患者（比值比0.
