Ho H N, Gill T J, Klionsky B, Ouyang P C, Hsieh C Y, Seski J, Kunschner A
Department of Obstetrics and Gynecology, National Taiwan University Hospital.
Am J Obstet Gynecol. 1989 Oct;161(4):942-8. doi: 10.1016/0002-9378(89)90758-8.
The prevalence of gestational trophoblastic tumors varies widely among different populations: it is lowest in whites (3 to 6/100,000) and highest in Chinese (68 to 202/100,000). This observation suggests that the origin of the disease is different in the two populations. To test this hypothesis, we examined couples in whom the woman developed a gestational trophoblastic tumor in a white population (Pittsburgh) and a Chinese population (Taiwan) for sharing of human leukocyte A, B, DR, and DQ antigens, which we consider markers for sharing of major histocompatibility complex-linked recessive genes affecting both embryogenesis and carcinogenesis. No human leukocyte antigen sharing occurred between partners in Pittsburgh, but there was significant human leukocyte antigen sharing in Taiwan. The latter couples shared human leukocyte antigen B (p less than 0.04) and human leukocyte antigen DQ (p less than 0.007) and shared three or more human leukocyte A, B, DR, and DQ antigens (p less than 0.02) significantly more frequently than did normal couples. However, there was no increased sharing of any specific human leukocyte antigen allele. These findings support the hypothesis that gestational trophoblastic tumors occur on a sporadic basis in whites and on a genetic basis in Chinese.
在白人中最低（3至6/10万），而在中国人群中最高（68至202/10万）。这一观察结果表明，该疾病在这两个人群中的起源不同。为了验证这一假设，我们研究了在白人人群（匹兹堡）和中国人群（台湾）中女方患妊娠滋养细胞肿瘤的夫妇，检测他们人类白细胞A、B、DR和DQ抗原的共享情况，我们将这些抗原视为影响胚胎发生和致癌作用的主要组织相容性复合体相关隐性基因共享的标志物。在匹兹堡的夫妇中，伴侣之间未出现人类白细胞抗原共享，但在台湾有显著的人类白细胞抗原共享。后一组夫妇共享人类白细胞抗原B（p<0.04）和人类白细胞抗原DQ（p<0.007），并且共享三种或更多人类白细胞A、B、DR和DQ抗原（p<0.02）的频率显著高于正常夫妇。然而，任何特定人类白细胞抗原等位基因的共享均未增加。这些发现支持了以下假设：妊娠滋养细胞肿瘤在白人中以散发性发生，而在中国人群中以遗传方式发生。
