Ober C L, Hauck W W, Kostyu D D, O'Brien E, Elias S, Simpson J L, Martin A O
Fertil Steril. 1985 Aug;44(2):227-32.
To elucidate further the reproductive effects of human leukocyte antigen (HLA) sharing among spouses, we have been investigating prospectively the relationship between HLA-A, -B, and -DR sharing and reproductive outcome in the Hutterites, a religious isolate that proscribes contraception. For the first time the reproductive effects of HLA-DR sharing in a fertile population is reported in this article. Median intervals from marriage to first through fifth births were longer among couples who shared more than one HLA-A, -B, or -DR antigen. Longer intervals were associated with increased spontaneous abortion rates among couples who shared HLA-DR antigens (27%), compared with couples who shared only HLA-A or -B antigens (9%) and couples who shared no antigens (12%). Median completed family sizes were 5.0, 8.5, and 8.0 among the groups, respectively. However, some couples who shared HLA-DR antigens experienced no spontaneous abortions, despite ten or more pregnancies. Therefore, although HLA-DR compatibility, per se, is not deleterious, our data suggest a potentially important role for undefined HLA-linked genes in normal pregnancy.
为了进一步阐明配偶间人类白细胞抗原（HLA）共享对生殖的影响，我们一直在前瞻性地研究HLA - A、- B和 - DR共享与哈特人（一个禁止避孕的宗教隔离群体）生殖结局之间的关系。本文首次报道了在可育人群中HLA - DR共享对生殖的影响。在共享一种以上HLA - A、- B或 - DR抗原的夫妇中，从结婚到第一胎至第五胎出生的中位间隔时间更长。与仅共享HLA - A或 - B抗原的夫妇（9%）以及不共享任何抗原的夫妇（12%）相比，共享HLA - DR抗原的夫妇中自然流产率增加（27%），且间隔时间更长。三组人群的平均家庭子女数分别为5.0、8.5和8.0。然而，一些共享HLA - DR抗原的夫妇尽管怀孕十次或更多次，但并未经历自然流产。因此，虽然HLA - DR兼容性本身并无危害，但我们的数据表明，未明确的HLA连锁基因在正常妊娠中可能起着重要作用。
