Personal Social Services Research Unit, London School of Economics and Political Science, London, UK.
Personal Social Services Research Unit, London School of Economics and Political Science, London, UK.
J Am Med Dir Assoc. 2015 Jan;16(1):63-70. doi: 10.1016/j.jamda.2014.10.020.
Cognitive Stimulation Therapy (CST) is effective and cost-effective for people with mild-to-moderate dementia when delivered biweekly over 7 weeks.
To examine whether longer-term (maintenance) CST is cost-effective when added to usual care.
Cost-effectiveness analysis within multicenter, single-blind, pragmatic randomized controlled trial; subgroup analysis for people taking acetylcholinesterase inhibitors (ACHEIs). A total of 236 participants with mild-to-moderate dementia received CST for 7 weeks. They were randomized to either weekly maintenance CST added to usual care or usual care alone for 24 weeks.
Although outcome gains were modest over 6 months, maintenance CST appeared cost-effective when looking at self-rated quality of life as primary outcome, and cognition (MMSE) and proxy-rated quality-adjusted life years as secondary outcomes. CST in combination with ACHEIs offered cost-effectiveness gains when outcome was measured as cognition.
Continuation of CST is likely to be cost-effective for people with mild-to-moderate dementia.
认知刺激疗法（CST）对于轻度至中度痴呆患者是有效且具有成本效益的，当每两周进行一次治疗并持续 7 周时效果最佳。
研究在常规护理的基础上增加长期（维持）CST 是否具有成本效益。
在多中心、单盲、实用随机对照试验中进行成本效益分析；对服用乙酰胆碱酯酶抑制剂（ACHEIs）的人群进行亚组分析。共有 236 名轻度至中度痴呆患者接受了为期 7 周的 CST 治疗。他们被随机分配到每周接受 CST 维持治疗并添加到常规护理中，或仅接受常规护理 24 周。
尽管在 6 个月内获得的结果收益不大，但当将自我评估的生活质量作为主要结果，认知（MMSE）和代理评估的质量调整生命年来作为次要结果时，维持 CST 似乎具有成本效益。当以认知作为结果衡量标准时，CST 与 ACHEIs 联合使用具有成本效益。
对于轻度至中度痴呆患者，继续进行 CST 可能具有成本效益。
