Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong SAR, China.
Center for Social Welfare Studies, Beijing Normal University, Beijing, China.
BMJ Open. 2021 Aug 17;11(8):e047560. doi: 10.1136/bmjopen-2020-047560.
As the largest and most rapidly ageing population, Chinese people are now the major driver of the continued growth in dementia prevalence globally. The need for evidence-based interventions in Chinese communities is urgent. Although a wide range of pharmacological and non-pharmacological interventions for dementia have been trialled in Chinese populations, the evidence has not been systematically synthesised. This systematic review and meta-analysis aims to map out the interventions for people living with dementia and their carers in Chinese communities worldwide and compare the effectiveness of these interventions.
This protocol followed the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols checklist. We will search Chinese (China National Knowledge Infrastructure, WanFang DATA) and English bibliographical databases (MEDLINE, EMBASE, PsycINFO, CINAHL Plus, Global Health, WHO Global Index Medicus, Virtual Health Library, Cochrane CENTRAL, Social Care Online, BASE, MODelling Outcome and cost impacts of interventions for DEMentia (MODEM) Toolkit, Cochrane Database of Systematic Reviews), complemented by hand searching of reference lists. We will include studies evaluating the effectiveness of interventions for dementia or mild cognitive impairment in Chinese populations, using a randomised controlled trial design, and published between January 2008 and June 2020. We will use a standardised form to extract data and Version 2 of the Cochrane risk-of-bias tool for randomised trials to assess the risk of bias of the included studies. Collected data will be fully interpreted with narrative synthesis and analysed using pairwise and network meta-analyses to pool intervention effects where sufficient information is available. We will perform subgroup analysis and meta-regression to explore potential reasons for heterogeneity.
No formal ethics approval is required for this protocol. The findings will facilitate the development of studies on interventions for dementia and timely inform dementia policymaking and practice. Planned dissemination channels include peer-reviewed publications, conference presentations, public events and websites.
CRD42019134135.
作为人口最多且老龄化速度最快的国家，中国人现在是全球痴呆症患病率持续增长的主要驱动力。因此，在华社区急需开展基于证据的干预措施。虽然已经在中国人群中尝试了广泛的药物和非药物干预措施，但这些证据尚未得到系统的综合。本系统评价和荟萃分析旨在绘制全球华人社区中痴呆症患者及其照料者的干预措施，并比较这些干预措施的效果。
本方案遵循《系统评价和荟萃分析报告的首选报告项目清单》。我们将检索中文（中国国家知识基础设施，万方数据）和英文文献数据库（MEDLINE、EMBASE、PsycINFO、CINAHL Plus、全球健康、世界卫生组织全球索引医学、虚拟健康图书馆、考科蓝中心、社会护理在线、BASE、MODelling Outcome and cost impacts of interventions for DEMentia (MODEM) Toolkit、考科蓝系统评价数据库），并辅以手工检索参考文献。我们将纳入评估针对中国人群的痴呆症或轻度认知障碍的干预措施的有效性的研究，使用随机对照试验设计，并于 2008 年 1 月至 2020 年 6 月发表。我们将使用标准化表格提取数据，并使用 Cochrane 随机试验偏倚风险工具（版本 2）评估纳入研究的偏倚风险。收集的数据将通过叙述性综合分析进行全面解释，并在有足够信息的情况下使用成对和网络荟萃分析来汇总干预效果。我们将进行亚组分析和荟萃回归分析，以探索异质性的潜在原因。
本方案不需要正式的伦理批准。研究结果将有助于痴呆症干预措施的研究发展，并及时为痴呆症的政策制定和实践提供信息。计划的传播渠道包括同行评议出版物、会议演讲、公共活动和网站。
C RD42019134135。
