通过曼尼希型反应合成一类新型贝蒂碱：高效、简便、无溶剂且一锅法 protocol。 （注：“protocol”直译为“方案”“协议”等，这里结合语境可能是指合成方法等，可根据实际情况灵活理解准确意思后进行表述调整，比如“合成方法”等）
Synthesis of a new class of Betti bases by the Mannich-type reaction: efficient, facile, solvent-free and one-pot protocol.
作者信息
Shahrisa Aziz, Teimuri-Mofrad Reza, Gholamhosseini-Nazari Mahdi
机构信息
Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, 5166614766, Tabriz, Iran,
出版信息
Mol Divers. 2015 Feb;19(1):87-101. doi: 10.1007/s11030-014-9559-x. Epub 2014 Dec 21.
A variety of organocatalysts has been screened for the synthesis of arylaminonaphthols. It has been shown that (N,N-dimethylethanolamine) is a highly efficient organocatalyst for the direct synthesis of a novel class of arylaminonaphthols via three-component condensation of 2-naphthol, aldehydes, and arylamines under solvent-free conditions. Mild, one-pot, and green reaction conditions, relatively short reaction times and good yields make this protocol highly significant. 25 new compounds have been synthesized by this method.
已筛选了多种有机催化剂用于芳基氨基萘酚的合成。结果表明，（N，N-二甲基乙醇胺）是一种高效的有机催化剂，可在无溶剂条件下通过2-萘酚、醛和芳基胺的三组分缩合直接合成一类新型芳基氨基萘酚。温和、一锅法和绿色的反应条件、相对较短的反应时间和良好的产率使该方法具有重要意义。通过该方法合成了25种新化合物。
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