Iftikhar Ramsha, Kamran Muhammad, Iftikhar Aleesha, Parveen Sadia, Naeem Naila, Jamil Nazia
Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, QLD, Australia.
Mol Divers. 2023 Feb;27(1):543-569. doi: 10.1007/s11030-022-10427-3. Epub 2022 Apr 21.
Well-known Betti bases are the products obtained by the one-pot multicomponent reaction of 1-naphthol/2-naphthol, aliphatic/aromatic aldehydes, and secondary amines, and this reaction is known as the Betti reaction. During recent years, due to the unveiling of the pharmacological and synthetic potential of Betti bases, a tremendous increase in the studies reporting novel synthetic methods for the efficient synthesis of Betti bases was observed. This review presents the recent key developments in the green synthesis of the Betti bases and accounts for the significant number of the literature reported during 2019-2022. Both catalyst free as well as the catalyst promoted synthesis (nanocatalyst, biocatalyst, transition metal catalyst, etc.) along with the synthetic applications (catalyst, ligands/chiral auxiliaries, and valuable synthons), optoelectronic applications (fluorescence sensors for phosgene gas, Hg, and Cr detection, quasi-reversible redox potential) and biological properties (anticancer agents, antioxidant, anti-inflammatory agents, antitubercular agents, pesticidal agents, anti-Alzheimer agents, Topoisomerase I inhibitors, YAP-TEAD interaction inhibitors, and DNA binding and cleavage activity) are discussed. There is a surge of interest for the development of the green and efficient Betti reaction for the construction of C-C and C-N bond in a single-step reaction accessing Betti bases as products. Along with key methodological developments for the green synthesis of Betti bases, their applications in synthetic organic chemistry, optoelectronic sensors, advanced materials synthesis, agrochemicals and pharmaceutically active scaffolds, during the period of 2019-2022, have been considered.
著名的贝蒂碱是通过1-萘酚/2-萘酚、脂肪族/芳香醛和仲胺的一锅多组分反应得到的产物，该反应被称为贝蒂反应。近年来，由于贝蒂碱的药理和合成潜力被揭示，报道高效合成贝蒂碱新方法的研究数量大幅增加。本综述介绍了贝蒂碱绿色合成的近期关键进展，并阐述了2019年至2022年期间报道的大量文献。文中讨论了无催化剂以及催化剂促进的合成方法（纳米催化剂、生物催化剂、过渡金属催化剂等），以及合成应用（催化剂、配体/手性助剂和有价值的合成子）、光电应用（用于光气、汞和铬检测的荧光传感器、准可逆氧化还原电位）和生物学特性（抗癌剂、抗氧化剂、抗炎剂、抗结核剂、杀虫剂、抗阿尔茨海默病剂、拓扑异构酶I抑制剂、YAP-TEAD相互作用抑制剂以及DNA结合和切割活性）。人们对开发绿色高效的贝蒂反应以在一步反应中构建C-C和C-N键并生成贝蒂碱产物的兴趣激增。除了贝蒂碱绿色合成的关键方法进展外，还考虑了它们在2019年至2022年期间在合成有机化学、光电传感器、先进材料合成、农用化学品和药物活性支架中的应用。
