Olyaei Abolfazl, Sadeghpour Mahdieh
Department of Chemistry, Payame Noor University (PNU) PO Box 19395-4697 Tehran Iran
Department of Chemistry, Takestan Branch, Islamic Azad University Takestan Iran.
RSC Adv. 2019 Jun 11;9(32):18467-18497. doi: 10.1039/c9ra02813g. eCollection 2019 Jun 10.
The multicomponent reaction between 2-naphthol, arylaldehydes and ammonia yields aminobenzylnaphthols in a process known as the Betti reaction, which was first uncovered at the beginning of the 20th century. Various methods have been reported for the synthesis of aminobenzylnaphthol (Betti base) and bis-Betti base derivatives using various types of naphthols, aromatic amines, heteroaromatic amines, and aliphatic and cyclic amines instead of ammonia or diamines and aliphatic and aromatic aldehydes or dialdehyde compounds under various conditions in recent years. The Betti reaction produces racemic and non-racemic aminobenzylnaphthol ligands. It is also clear that the most important area of application of the non-racemic aminonaphthols prepared in this manner is their use in asymmetric synthesis, either as chiral ligands or as chiral auxiliaries. The functional groups in these Mannich products offer many ring closure possibilities. Some of these products or the starting bifunctional compounds possess biological activity. Herein, we present a selection of the relevant studies on this topic.
2-萘酚、芳醛和氨之间的多组分反应会生成氨基苄基萘酚，此过程称为贝蒂反应，该反应于20世纪初首次被发现。近年来，已经报道了各种方法，可在不同条件下使用各种类型的萘酚、芳香胺、杂芳香胺以及脂肪族和环状胺来代替氨或二胺以及脂肪族和芳香醛或二醛化合物，以合成氨基苄基萘酚（贝蒂碱）和双贝蒂碱衍生物。贝蒂反应会生成外消旋和非外消旋的氨基苄基萘酚配体。同样明显的是，以这种方式制备的非外消旋氨基萘酚最重要的应用领域是其在不对称合成中的用途，既可以作为手性配体，也可以作为手性助剂。这些曼尼希产物中的官能团提供了许多闭环可能性。其中一些产物或起始双官能化合物具有生物活性。在此，我们展示了关于该主题的一些相关研究。
