Burke A P, Sobin L H
Department of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.
Am J Surg Pathol. 1989 Nov;13(11):940-6. doi: 10.1097/00000478-198911000-00004.
We studied Cronkhite-Canada (CC) polyps from nine patients, and compared them to gastric and colonic juvenile and gastric hyperplastic polyps. The CC polyp is characterized by its broad sessile base, expanded edematous lamina propria, and cystic glands. Similar features are found in the lesions of juvenile polyposis and gastric hyperplastic polyps. The only reliable distinction between CC and colonic juvenile polyposis was the pedunculated growth of the latter; however, this feature did not hold for gastric lesions. Unlike CC polyps, juvenile polyps sometimes have areas of dysplasia, but this is not typical. Therefore the diagnosis of CC polps, especially when located in the stomach, requires the presence of the ectodermal changes characteristic of this syndrome.
我们研究了9例克朗凯特-加拿大（CC）息肉患者，并将其与胃和结肠幼年性息肉以及胃增生性息肉进行了比较。CC息肉的特征在于其宽基底无蒂、固有层水肿扩张以及囊性腺体。幼年性息肉病和胃增生性息肉的病变也有类似特征。CC息肉与结肠幼年性息肉病之间唯一可靠的区别是后者有蒂生长；然而，这一特征在胃部病变中并不成立。与CC息肉不同，幼年性息肉有时会出现发育异常区域，但这并不典型。因此，CC息肉的诊断，尤其是位于胃部时，需要存在该综合征特有的外胚层改变。
