Fletcher C V, Englund J A, Bean B, Chinnock B, Brundage D M, Balfour H H
Department of Pharmacy Practice, University of Minnesota, Health Sciences Center, Minneapolis 55455.
Antimicrob Agents Chemother. 1989 Aug;33(8):1375-8. doi: 10.1128/AAC.33.8.1375.
Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 mumol/liter. Of 12 patients who had continuous infusion for greater than 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.
13名对阿昔洛韦间歇给药至少72小时无反应的疱疹病毒感染患者接受了大剂量持续输注。稳态浓度维持在20至98微摩尔/升之间。在12名接受持续输注超过5天的患者中，根据临床和病毒学参数判定，7名（58%）患者的感染得到解决，这表明持续输注可能对某些对传统治疗无反应的患者有效。
