Castellano C, Brioni J D, Nagahara A H, McGaugh J L
Istituto di Psicobiologia e Psicofarmacologia del CNR, Roma, Italy.
Behav Neural Biol. 1989 Sep;52(2):170-9. doi: 10.1016/s0163-1047(89)90285-9.
The effects of the GABA-B receptor agonist baclofen on memory storage were studied in two series of experiments. In the first series, CD-1 mice were trained in two aversively motivated tasks: a one-trial inhibitory avoidance task and a classical conditioning task (conditional emotional response). Immediate post-training ip administration of (+/-)baclofen (10 and 30 mg/kg) impaired retention of animals in both tasks. The effect was time-dependent: Retention was not affected by baclofen administered 120 min after training. In the second series of experiments, which used Sprague-Dawley rats, post-training intra-amygdala administration of baclofen impaired retention of an inhibitory avoidance response. These results support the view that the GABAergic system is involved in the modulation of memory storage and that the amygdaloid complex may be a critical site for effects of drugs affecting the GABAergic system.
在两个系列的实验中研究了γ-氨基丁酸B（GABA-B）受体激动剂巴氯芬对记忆储存的影响。在第一个系列中，对CD-1小鼠进行了两项厌恶性动机任务训练：一次性抑制性回避任务和经典条件反射任务（条件性情绪反应）。训练后立即腹腔注射（±）巴氯芬（10和30mg/kg）会损害动物在这两项任务中的记忆保持。这种作用具有时间依赖性：训练后120分钟给予巴氯芬对记忆保持没有影响。在使用斯普拉格-道利大鼠的第二个系列实验中，训练后杏仁核内注射巴氯芬会损害抑制性回避反应的记忆保持。这些结果支持以下观点：γ-氨基丁酸能系统参与记忆储存的调节，并且杏仁复合体可能是影响γ-氨基丁酸能系统的药物发挥作用的关键部位。
