Liang K C, Hon W, Davis M
Department of Psychology, National Taiwan University, Taipei, Republic of China.
Behav Neurosci. 1994 Apr;108(2):241-53. doi: 10.1037//0735-7044.108.2.241.
Involvement of amygdaloid N-methyl-D-aspartate (NMDA) receptors in memory processes was investigated. Rats with cannulas implanted in the basolateral amygdala were trained on a 1 trial step-through inhibitory avoidance task and tested for 24-hr retention. Pretraining infusion of 2-amino-5-phosphonovaleric acid (APV) into the amygdala, but not striatum or hippocampus, produced a dose-dependent retention deficit, which was attenuated by immediate posttraining intra-amygdala infusion of NMDA. Posttraining APV infusion also caused a dose- and time-dependent retention deficit. Pretest APV infusion had no effect on performance in the retention test. Further, pre- or posttraining infusion of 5.0 micrograms APV failed to affect acquisition and retention in the Morris water maze task. These findings suggest that amygdala NMDA receptors are normally activated by aversive training and play a critical role in memory formation for affective experience.
研究了杏仁核N-甲基-D-天冬氨酸（NMDA）受体在记忆过程中的作用。将套管植入基底外侧杏仁核的大鼠接受单次步通抑制性回避任务训练，并测试其24小时记忆保持情况。在训练前将2-氨基-5-磷酸戊酸（APV）注入杏仁核而非纹状体或海马体，会产生剂量依赖性的记忆保持缺陷，而在训练后立即向杏仁核内注入NMDA可减轻该缺陷。训练后注入APV也会导致剂量和时间依赖性的记忆保持缺陷。预测试时注入APV对记忆保持测试中的表现没有影响。此外，在训练前或训练后注入5.0微克APV不会影响莫里斯水迷宫任务中的习得和记忆保持。这些发现表明，杏仁核NMDA受体通常在厌恶训练中被激活，并在情感体验的记忆形成中起关键作用。
