Treat Eric G, Schulam Peter G, Gritsch Hans A, Liu Chia-Hung, Xiong Siwei, Passos Felipe, Chuang Ryan, Hu Jim C
Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Department of Urology, Yale School of Medicine, New Haven, CT.
Urology. 2015 Jan;85(1):107-12. doi: 10.1016/j.urology.2014.09.027.
To describe and illustrate the evolution of surgical technique, emphasizing technical modifications of laparoscopic donor nephrectomy (LDN) and the impact on complication outcome.
This is a retrospective observational study of prospectively collected data on all consecutive purely LDN surgeries performed at a tertiary academic medical center (n = 1325), performed between March 2000 and October 2013.
Over time, LDN was performed on older patients, changing from a mean of 35.7 years in 2000 to 41.2 years in 2013 (P <.001). Additionally, mean blood loss decreased from 75 mL in 2000 to 21.6 mL in 2013 (P <.001). However, body mass index, operative time, and length of stay remained similar. Overall, there were 105 (7.9%) complications: Clavien grade 1 (n = 81, 6.1%) and grade 2 or higher (n = 23, 1.8%). Procedure duration, blood loss, surgeon, year of procedure, laterality, body mass index, age, and gender did not significantly predict complications. There was no significant difference for Clavien complication rates between the early learning period (first 150 cases) and the rest of the series.
With continual refinement with LDN techniques based on intraoperative observations and technological advances, complication rates remain consistently low, despite increasing donor age.
描述并阐述手术技术的演变,重点强调腹腔镜供肾切除术(LDN)的技术改进及其对并发症结局的影响。
这是一项回顾性观察研究,对一所三级学术医学中心在2000年3月至2013年10月期间连续进行的所有单纯LDN手术(n = 1325)的前瞻性收集数据进行分析。
随着时间的推移,接受LDN手术的患者年龄逐渐增大,从2000年的平均35.7岁变为2013年的41.2岁(P <.001)。此外,平均失血量从2000年的75 mL降至2013年的21.6 mL(P <.001)。然而,体重指数、手术时间和住院时间保持相似。总体而言,共有105例(7.9%)并发症:Clavien 1级(n = 81,6.1%)和2级或更高级别(n = 23,1.8%)。手术持续时间、失血量、外科医生、手术年份、手术侧别、体重指数、年龄和性别均不能显著预测并发症。早期学习阶段(前150例)与系列其余病例的Clavien并发症发生率无显著差异。
基于术中观察和技术进步,LDN技术不断完善,尽管供体年龄增加,但并发症发生率始终保持在较低水平。