Watanabe T, Yamori T, Akazawa H
Division of Development of Scientific Research, Kansai Medical Laboratory (FALCO Biosystems Company), Kyoto, Japan.
Zentralbl Bakteriol. 1989 Sep;271(3):330-8. doi: 10.1016/s0934-8840(89)80031-3.
The mean survival age of female AKR/J mice was significantly prolonged, the enlargement of thymus was markedly suppressed, and the proliferation of ecotropic and recombinant murine leukemia viruses was inhibited when 2-month-old female AKR/J mice were injected intraperitoneally with attenuated Streptococcus pyogenes, strain Su (OK-432) twice weekly for 8 weeks. However, these effects of OK-432 in 2-month-old female AKR/J mice were not seen in 5-month-old female AKR/J mice. The difference in the effectiveness of OK-432 in these animals probably depends on the difference in the degree of the proliferation of ecotropic and recombinant murine leukemia viruses in the thymus which consequently lead to thymic lymphoma.
当对2月龄雌性AKR/J小鼠每周两次腹腔注射减毒化脓性链球菌菌株Su（OK-432），持续8周时，雌性AKR/J小鼠的平均生存年龄显著延长，胸腺肿大明显受到抑制，嗜亲性和重组鼠白血病病毒的增殖受到抑制。然而，在5月龄雌性AKR/J小鼠中未观察到OK-432对2月龄雌性AKR/J小鼠的这些作用。OK-432在这些动物中的有效性差异可能取决于胸腺中嗜亲性和重组鼠白血病病毒增殖程度的差异，进而导致胸腺淋巴瘤。
