Tseng Yi-Hsin, Yeh Yung-Hsin, Chen Wei-Jan, Lin Kwang-Huei
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
First Cardiovascular Division, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Int J Mol Sci. 2014 Dec 18;15(12):23640-57. doi: 10.3390/ijms151223640.
Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, thyroid hormone, irisin and caloric intake, are usually relevant to energy expenditure or thermogenesis. In murine models, serum triglyceride levels as well as pancreatic cell proliferation are potently enhanced by betatrophin. Intriguingly, conflicting phenomena have also been reported that betatrophin suppresses hepatic triglyceride levels, suggesting that betatrophin function is mediated by complex regulatory processes. However, its precise physiological role remains unclear at present. In this review, we have summarized the current findings on betatrophin and their implications.
β-促细胞生成素，也被称为TD26/RIFL/脂肪酶/血管生成素样蛋白8/C19orf80，是一种主要在人类肝脏中表达的新型蛋白质。迄今为止，已在哺乳动物中鉴定出几种β-促细胞生成素的直系同源物。越来越多的证据表明，β-促细胞生成素的表达与血清脂质谱之间存在关联，尤其是在肥胖或糖尿病患者中。β-促细胞生成素的刺激物，如胰岛素、甲状腺激素、鸢尾素和热量摄入，通常与能量消耗或产热有关。在小鼠模型中，β-促细胞生成素能有效提高血清甘油三酯水平以及胰腺细胞增殖。有趣的是，也有相互矛盾的现象报道称β-促细胞生成素会抑制肝脏甘油三酯水平，这表明β-促细胞生成素的功能是由复杂的调节过程介导的。然而，其确切的生理作用目前仍不清楚。在这篇综述中，我们总结了关于β-促细胞生成素的当前研究结果及其意义。
