Hellstrom Wayne J G, Wang Run, Kadowitz Philip J, Domer Floyd R
Departments of Urology and Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Int J Impot Res. 1992;4:35-43.
Using a feline model, erections caused by a new class of vasodilator agents that specifically activate potassium (K-ATP) channels (lemakalim, nicorandil, and pinacidil) were compared to baseline and maximal erections induced by a standard drug combination (1.65 mg papaverine, 25 μg phentolamine and 0.5 μg PGE) injected intracavernosally. The responses were characterized by the maximal intracavernosal pressure, the duration of maximal pressure, the total duration of drug effect, the change in penile length, and alterations in systemic arterial blood pressure. All three K-ATP channel openers caused erections in a dose-dependent manner. All agents caused similar increases in penile length with full erection, but the duration of maximal pressure and duration of action were significantly shorter (<0.01) than with the standard drug combination. Lemakalim did not decrease systemic blood pressure as did nicorandil, pinacidil, and the standard drug combination. This study supports the use of an in-vivo feline model for the evaluation of vasoactive agents and suggests that a new class of agents can pharmacologically activate the erectile response selectively by an alternate pathway.
利用猫科动物模型，将一类新型的特异性激活钾（K-ATP）通道的血管扩张剂（雷马卡林、尼可地尔和平卡地尔）所引起的勃起，与通过海绵体内注射标准药物组合（1.65毫克罂粟碱、25微克酚妥拉明和0.5微克前列腺素E）诱导的基线勃起和最大勃起进行比较。通过海绵体内最大压力、最大压力持续时间、药物作用总持续时间、阴茎长度变化以及全身动脉血压变化来表征这些反应。所有三种K-ATP通道开放剂均以剂量依赖性方式引起勃起。所有药物在完全勃起时均使阴茎长度有类似增加，但最大压力持续时间和作用持续时间比标准药物组合显著更短（<0.01）。雷马卡林不像尼可地尔、平卡地尔和标准药物组合那样降低全身血压。本研究支持使用体内猫科动物模型来评估血管活性药物，并表明一类新型药物可通过另一种途径在药理学上选择性激活勃起反应。
