Wang R, Higuera T R, Sikka S C, Minkes R K, Bellan J A, Kadowitz P J, Domer F R, Hellstrom W J
Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112.
Urol Res. 1993 Jan;21(1):75-8. doi: 10.1007/BF00295198.
The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats. The maximal erectile response (intracavernous pressure, penile length, and rigidity) was produced by intracavernous injection of a combination of 1.65 mg papaverine, 0.5 micrograms PGE1, and 25 micrograms phentolamine. This combination was considered as "control" in order to compare the effect of other agents. VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5 micrograms VIP or 10 micrograms SNP. The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P < 0.01). Epinephrine (30 micrograms) reversed the effects of SNP and significantly shortened the duration of peak action and total effect (P < 0.05). This study supports the use of an in vivo feline model for the evaluation of vasoactive agents and demonstrates that the intracavernous injection of either VIP or SNP can induce penile erection in the adult cat.
在22只成年猫身上研究了血管活性肠肽（VIP）、硝普钠（SNP）以及罂粟碱、前列腺素E1和酚妥拉明的参考组合的使用情况。海绵体内注射1.65毫克罂粟碱、0.5微克前列腺素E1和25微克酚妥拉明的组合可产生最大勃起反应（海绵体内压、阴茎长度和硬度）。为了比较其他药物的效果，该组合被视为“对照”。VIP和SNP以剂量依赖性方式增加海绵体内压并导致勃起，5微克VIP或10微克SNP可获得最大反应。与参考组合相比，VIP和SNP导致的勃起峰值持续时间和药物作用总持续时间明显更短（P < 0.01）。肾上腺素（30微克）可逆转SNP的作用，并显著缩短峰值作用持续时间和总作用持续时间（P < 0.05）。本研究支持使用体内猫模型评估血管活性药物，并表明海绵体内注射VIP或SNP均可诱导成年猫阴茎勃起。
