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蛇毒成分及其交叉反应性:综述

Snake venom components and their cross-reactivity: a review.

作者信息

Berger B J, Bhatti A R

机构信息

Toxicology and Infectivity Group, Biomedical Defense Section, Defense Research Establishment Suffield, Ralston, Alta., Canada.

出版信息

Biochem Cell Biol. 1989 Sep;67(9):597-601. doi: 10.1139/o89-092.

Abstract

Snake venoms are complex mixtures of organic and inorganic compounds, many of which display biological activity. It has been demonstrated that antisera raised against whole venom or a single purified venom protein from one species of snake will react with proteins in the venom of other species. This cross-reactivity between species may have applications in determining snake phylogeny, but recent studies on the variation of venom components within a species make these evolutionary conclusions questionable.

摘要

蛇毒是有机和无机化合物的复杂混合物,其中许多都具有生物活性。已经证明,针对一种蛇的全毒液或单一纯化毒液蛋白产生的抗血清会与其他蛇种毒液中的蛋白质发生反应。物种间的这种交叉反应性可能在确定蛇的系统发育方面有应用,但最近关于一个物种内毒液成分变异的研究使这些进化结论受到质疑。

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