Tyagi Asha, Venkateswaran Vineeta, Jain Ajai Kumar, Verma Uttam Chandra
Department of Anaesthesiology and Critical Care, University College of Medical Sciences and GTB Hospital, Shahdara, Delhi 110095, India.
Anesthesiol Res Pract. 2014;2014:459432. doi: 10.1155/2014/459432. Epub 2014 Oct 29.
Background. This study aimed to evaluate and compare total cost of sevoflurane and propofol for 1.0 MAC-hour of anaesthesia, employing three anaesthetic techniques. Methods. Adult patients scheduled for surgical procedures under general anaesthesia anticipated to last approximately an hour were randomized into three groups (n = 15 each), to receive anaesthesia using one of the following techniques: low flow technique involving induction with propofol, followed by sevoflurane delivered using initial fresh gas flows of 6 L/min till MAC reached 1.0 and then reduced to 0.5 L/min; alternate method of low flow entailing only a difference in fresh gas flow rates being maintained at 1 L/min throughout; the third technique involving use of sevoflurane for both induction and maintenance of anaesthesia. Results. Cost of sevoflurane to maintain 1 MAC-hour of anaesthesia was clinically least with low flow anaesthesia, though statistically similar amongst the three techniques. Once the cost of propofol used for induction in two of the three groups was added to that of sevoflurane, cost incurred was least with the technique using sevoflurane both for induction and maintenance of anaesthesia, as compared to low flow and alternative low flow techniques, a 26% and 32% cost saving, respectively (P < 0.05).
背景。本研究旨在采用三种麻醉技术，评估和比较七氟醚和丙泊酚维持1.0 MAC小时麻醉的总成本。方法。计划接受预计持续约1小时全身麻醉手术的成年患者被随机分为三组（每组n = 15），使用以下技术之一接受麻醉：低流量技术，即先使用丙泊酚诱导，随后使用七氟醚，初始新鲜气体流量为6 L/分钟，直至达到1.0 MAC，然后降至0.5 L/分钟；另一种低流量方法，仅在整个过程中维持新鲜气体流量为1 L/分钟；第三种技术是在麻醉诱导和维持过程中均使用七氟醚。结果。低流量麻醉时，维持1 MAC小时麻醉的七氟醚成本在临床上最低，尽管三种技术在统计学上相似。将三组中两组用于诱导的丙泊酚成本加入七氟醚成本后，与低流量和替代低流量技术相比，在麻醉诱导和维持过程中均使用七氟醚的技术成本最低，分别节省成本26%和32%（P < 0.05）。
