[Sigma receptors of the loach embryo regulate ornithine decarboxylase activity].

When loach embryos (Miagurnus fossilis) were incubated with opioid substance, sigma-receptors ligand SKF 10.047, activity of the key enzyme of polyamine synthesis - ornithine decarboxylase (ODC), increased. A correlation between teratogenic and ODC-stimulated action of SKF 10.047 was stage-specific and depend on opioid concentration. Possible mechanism of embryonic cell aggregation under SKF 10.047 action and polyamines role in that process is discussed.