Kaliuzhnyĭ A E, Iarygin K N, Sukhikh G T
Biull Eksp Biol Med. 1989 Jul;108(7):97-8.
When loach embryos (Miagurnus fossilis) were incubated with opioid substance, sigma-receptors ligand SKF 10.047, activity of the key enzyme of polyamine synthesis - ornithine decarboxylase (ODC), increased. A correlation between teratogenic and ODC-stimulated action of SKF 10.047 was stage-specific and depend on opioid concentration. Possible mechanism of embryonic cell aggregation under SKF 10.047 action and polyamines role in that process is discussed.
当泥鳅胚胎（Misgurnus fossilis）与阿片样物质、σ受体配体SKF 10.047一起孵育时，多胺合成的关键酶——鸟氨酸脱羧酶（ODC）的活性增加。SKF 10.047的致畸作用与ODC刺激作用之间的相关性具有阶段特异性，且取决于阿片样物质的浓度。本文讨论了在SKF 10.047作用下胚胎细胞聚集的可能机制以及多胺在该过程中的作用。
