Kaliuzhnyĭ A E, Cherdantsev V G
Zh Evol Biokhim Fiziol. 1988 Nov-Dec;24(6):808-16.
SKF 10,047, known as an agonist of sigma opiate receptors of the brain, specifically interacts with the surface of embryonic cells of the loach inducing clustering of concanavalin A receptors, changing rheological properties of the membrane and causing the detachment of the cultivated cells from the glass. Both, in situ and in vitro, the rate of cellular aggregation increases together with the increase in the local density of aggregates; aggregation looses its spatial homogeneity. Therefore, there is a direct relationship between destabilization of spatially homogeneous condition at the cellular and supracellular levels.
SKF 10,047，作为大脑西格玛阿片受体的激动剂，与泥鳅胚胎细胞表面特异性相互作用，诱导伴刀豆球蛋白A受体聚集，改变膜的流变学性质，并导致培养细胞从玻璃上脱离。在原位和体外，细胞聚集速率都随着聚集体局部密度的增加而增加；聚集失去其空间均匀性。因此，在细胞和超细胞水平上，空间均匀条件的不稳定之间存在直接关系。
