Komissarova E V, Tolpygo S M, Polyntsev Iu V, Krizhevskaia Iu V, Shestakov P A, Kotov A V, Gomazkov O A
Biull Eksp Biol Med. 1989 Aug;108(8):181-5.
Angiotensin-converting enzyme (ACE) activity in serum and some brain areas, level of angiotensin I in the blood and drinking behaviour during immunization of rats against conjugate of angiotensin II with bovine serum albumin (BSA) were studied. The results show that an increase in antibodies against angiotensin II was correlated with elevated ACE activity in serum. There was a distinct tendency towards elevated level of angiotensin I in the blood. After a 6 month's immunization ACE-activity was reduced twofold to threefold in midbrain and hypothalamus-thalamus. During immunization water-uptake was increased by 40-45%.
研究了大鼠针对血管紧张素 II 与牛血清白蛋白（BSA）结合物免疫期间血清和一些脑区的血管紧张素转换酶（ACE）活性、血液中血管紧张素 I 的水平及饮水行为。结果表明，抗血管紧张素 II 抗体的增加与血清中 ACE 活性升高相关。血液中血管紧张素 I 水平有明显升高趋势。免疫 6 个月后，中脑和下丘脑 - 丘脑的 ACE 活性降低了两倍至三倍。免疫期间水摄入量增加了 40 - 45%。
