Radmanesh Alireza, Zamani Amir A, Whalen Stephen, Tie Yanmei, Suarez Ralph O, Golby Alexandra J
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA.
Clin Neurol Neurosurg. 2015 Feb;129:44-9. doi: 10.1016/j.clineuro.2014.11.021. Epub 2014 Dec 8.
To compare five different seeding methods to delineate hand, foot, and lip components of the corticospinal tract (CST) using single tensor tractography.
We studied five healthy subjects and 10 brain tumor patients. For each subject, we used five different seeding methods, from (1) cerebral peduncle (CP), (2) posterior limb of the internal capsule (PLIC), (3) white matter subjacent to functional MRI activations (fMRI), (4) whole brain and then selecting the fibers that pass through both fMRI and CP (WBF-CP), and (5) whole brain and then selecting the fibers that pass through both fMRI and PLIC (WBF-PLIC). Two blinded neuroradiologists rated delineations as anatomically successful or unsuccessful tractography. The proportions of successful trials from different methods were compared by Fisher's exact test.
To delineate hand motor tract, seeding through fMRI activation areas was more effective than through CP (p<0.01), but not significantly different from PLIC (p>0.1). WBF-CP delineated hand motor tracts in a larger proportion of trials than CP alone (p<0.05). Similarly, WBF-PLIC depicted hand motor tracts in a larger proportion of trials than PLIC alone (p<0.01). Foot motor tracts were delineated in all trials by either PLIC or whole brain seeding (WBF-CP and WBF-PLIC). Seeding from CP or fMRI activation resulted in foot motor tract visualization in 87% of the trials (95% confidence interval: 60-98%). The lip motor tracts were delineated only by WBF-PLIC and in 36% of trials (95% confidence interval: 11-69%).
Whole brain seeding and then selecting the tracts that pass through two anatomically relevant ROIs can delineate more plausible hand and lip motor tracts than seeding from a single ROI. Foot motor tracts can be successfully delineated regardless of the seeding method used.
使用单张量纤维束成像比较五种不同的种子点放置方法来描绘皮质脊髓束（CST）的手部、足部和唇部成分。
我们研究了5名健康受试者和10名脑肿瘤患者。对于每个受试者，我们使用了五种不同的种子点放置方法，分别是：（1）大脑脚（CP），（2）内囊后肢（PLIC），（3）功能磁共振成像激活（fMRI）下方的白质，（4）全脑然后选择穿过fMRI和CP的纤维（WBF-CP），以及（5）全脑然后选择穿过fMRI和PLIC的纤维（WBF-PLIC）。两名不知情的神经放射科医生将纤维束成像的描绘评定为解剖学上成功或不成功。通过Fisher精确检验比较不同方法成功试验的比例。
为了描绘手部运动束，通过fMRI激活区域放置种子点比通过CP更有效（p<0.01），但与PLIC无显著差异（p>0.1）。在比单独使用CP更大比例的试验中，WBF-CP描绘了手部运动束（p<0.05）。同样，在比单独使用PLIC更大比例的试验中，WBF-PLIC描绘了手部运动束（p<0.01）。通过PLIC或全脑种子点放置（WBF-CP和WBF-PLIC）在所有试验中都描绘出了足部运动束。从CP或fMRI激活处放置种子点在87%的试验中实现了足部运动束的可视化（95%置信区间：60-98%）。唇部运动束仅由WBF-PLIC描绘，且在36%的试验中描绘成功（95%置信区间：11-69%）。
与从单个感兴趣区域（ROI）放置种子点相比，全脑放置种子点然后选择穿过两个解剖学相关ROI的纤维束可以描绘出更合理的手部和唇部运动束。无论使用何种种子点放置方法，足部运动束都能成功描绘。
