Kocak Mehmet, Ulmer John L, Sahin Ugurel M, Gaggl Wolfgang, Prost Robert W
Medical College of Wisconsin, Department of Radiology, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA.
Radiology. 2009 May;251(2):485-92. doi: 10.1148/radiol.2512080231. Epub 2009 Mar 4.
To determine the concurrence of activation in the primary motor cortex, induced by paradigms of active and passive movement of extremities, by using blood oxygen level-dependent functional magnetic resonance (MR) imaging.
The HIPAA-compliant study was approved by the institutional review board, and written informed consent was obtained from the participating volunteers. Functional MR imaging data were collected from 11 healthy volunteers (four women, seven men; age range, 24-42 years) during active and passive movements of hand, elbow, shoulder, ankle, knee, and hip. These data were then mapped onto three-dimensional anatomic images. Volumes of activation were determined by using cross-correlation analysis at a coefficient threshold of 0.4 (P < .01). Regions of interest were drawn in pre- and postcentral gyri based on anatomic criteria. The mean number of activated voxels in the pre- and postcentral gyri induced by active and passive movements was compared by using Wilcoxon analysis. Concurrence ratios and proportional ratios of activation between active and passive movements were calculated for each somatotopic location.
Primary motor cortex activation tended to increase with active compared with passive movements, although in the precentral gyrus, hand, elbow, and shoulder movements showed no statistically significant difference in mean number of activated voxels. In the postcentral gyrus, only the shoulder revealed a significant difference (P < .05). Concurrence ratios (activation volume overlap of two tasks/combined activation area of both tasks) ranged from 0.44 to 0.57. Proportional ratios (activation volume overlap of passive task with active task/total activation volume of passive task) ranged from 0.64 to 0.82.
Passive movement paradigms may be an alternative to or complement to active movement tasks in patient populations.
通过使用血氧水平依赖性功能磁共振成像，确定肢体主动和被动运动范式所诱发的初级运动皮层激活的一致性。
这项符合健康保险流通与责任法案（HIPAA）的研究获得了机构审查委员会的批准，并获得了参与志愿者的书面知情同意书。在手部、肘部、肩部、脚踝、膝盖和臀部的主动和被动运动过程中，从11名健康志愿者（4名女性，7名男性；年龄范围24 - 42岁）收集功能磁共振成像数据。然后将这些数据映射到三维解剖图像上。通过使用系数阈值为0.4（P <.01）的互相关分析来确定激活体积。根据解剖学标准在中央前回和中央后回绘制感兴趣区域。使用Wilcoxon分析比较主动和被动运动在中央前回和中央后回诱发的激活体素的平均数量。计算每个躯体定位部位主动和被动运动之间激活的一致性比率和比例比率。
与被动运动相比，主动运动时初级运动皮层激活倾向于增加，尽管在中央前回，手部、肘部和肩部运动在激活体素的平均数量上没有统计学显著差异。在中央后回，只有肩部显示出显著差异（P <.05）。一致性比率（两个任务的激活体积重叠/两个任务的联合激活面积）范围为0.44至0.57。比例比率（被动任务与主动任务的激活体积重叠/被动任务的总激活体积）范围为0.64至0.82。
在患者群体中，被动运动范式可能是主动运动任务的替代或补充。
