Wauquier I, Devynck M A
Department of Pharmacology, INSERM U7, CNRS UA 318, Necker Hospital, Paris, France.
Clin Exp Hypertens A. 1989;11(7):1217-34. doi: 10.3109/10641968909038166.
Circulating digitalis-like compounds have been proposed to be raised in volume expanded hypertension and to participate in Na+ homeostasis. We have investigated the temporal relationships between the activity of these circulating digitalis-like compounds, blood pressure and body fluid volume variations during a chronic NaCl load in the Wistar rat. Characteristics of salt-loaded rats were compared to those of weight-matched controls. At one week, when extracellular fluid volume (ECFV) was elevated, the capacity of plasma extracts to inhibit the Na+K+ATPase activity begun to rise. At two weeks, ECFV remained elevated, and plasma volume, blood pressure and the activity of plasma digitalis-like compounds increased. After 13 weeks, the continuous rise in plasma digitalis-like activity and in blood pressure was accompanied by the return of body fluid volumes towards control values. These changes in plasma digitalis-like activity, body fluid volumes, and systolic blood pressure during a high NaCl diet are compatible with the proposed role of circulating digitalis-like compounds as natriuretic and hypertensive factors.
循环中类洋地黄化合物被认为在容量扩张型高血压中水平升高，并参与钠稳态。我们研究了在Wistar大鼠慢性氯化钠负荷期间，这些循环中类洋地黄化合物的活性、血压和体液量变化之间的时间关系。将盐负荷大鼠的特征与体重匹配的对照大鼠进行比较。在一周时，当细胞外液量（ECFV）升高时，血浆提取物抑制钠钾ATP酶活性的能力开始上升。在两周时，ECFV仍升高，血浆量、血压和血浆类洋地黄化合物的活性增加。13周后，血浆类洋地黄活性和血压持续升高，同时体液量恢复到对照值。高氯化钠饮食期间血浆类洋地黄活性、体液量和收缩压的这些变化与循环中类洋地黄化合物作为利钠和高血压因子的推测作用相符。
