Wauquier I, Pernollet M G, Delva P, Lacour B, Devynck M A
J Hypertens. 1986 Aug;4(4):463-9. doi: 10.1097/00004872-198608000-00011.
The effects of a high salt diet (8% NaCl) on blood pressure and intra-erythrocytic Na+ content were studied in Wistar rats. The ability of the plasma to inhibit the renal Na+,K+-ATPase activity and to cross-react with digoxin antibodies was also investigated. After 1 week, neither systolic blood pressure nor intra-erythrocytic Na+ content were modified, but plasma extracts slightly inhibited renal Na+,K+-ATPase (70.9 +/- 1.7 versus 76.3 +/- 2.1 mumol Pi/mg per h, P = 0.05). After 2 weeks, the plasma inhibitory activity, systolic blood pressure and intra-erythrocytic Na+ content were higher than corresponding values in control animals (65.5 +/- 1.6 versus 79.1 +/- 2.8 mol Pi/mg per h, P less than 0.001; 132 +/- 2 versus 114 +/- 4 mmHg, P less than 0.001, and 4.95 +/- 0.32 versus 3.81 +/- 0.36 mmol/l cells, P less than 0.05, respectively). After 3 months, the plasma digoxin-like immunoreactivity and its ability to inhibit the Na+ pump were elevated (68.7 +/- 7.9 versus 48.2 +/- 5.4 pg/ml, P less than 0.02; 57.8 +/- 1.8 versus 72.9 +/- 1.8 mumol Pi/mg per h, P less than 0.001, respectively) whereas intra-erythrocytic Na+ content had returned to control levels. The results demonstrated that this high salt intake led to simultaneous increases in systolic blood pressure and in the activity of a digitalis-like compound present in plasma. The inhibition of Na+,K+-ATPase was correlated with systolic blood pressure and digoxin-like immunoreactivity (r = 0.569, n = 76, P less than 0.001 and r = 0.414, n = 34, P less than 0.02, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
在Wistar大鼠中研究了高盐饮食（8%氯化钠）对血压和红细胞内钠离子含量的影响。还研究了血浆抑制肾钠钾ATP酶活性以及与地高辛抗体交叉反应的能力。1周后，收缩压和红细胞内钠离子含量均未改变，但血浆提取物轻微抑制肾钠钾ATP酶（70.9±1.7对76.3±2.1微摩尔无机磷/毫克每小时，P = 0.05）。2周后，血浆抑制活性、收缩压和红细胞内钠离子含量均高于对照动物的相应值（65.5±1.6对79.1±2.8微摩尔无机磷/毫克每小时，P<0.001；132±2对114±4毫米汞柱，P<0.001，以及4.95±0.32对3.81±0.36毫摩尔/升细胞，P<0.05）。3个月后，血浆地高辛样免疫反应性及其抑制钠泵的能力升高（68.7±7.9对48.2±5.4皮克/毫升，P<0.02；57.8±1.8对72.9±1.8微摩尔无机磷/毫克每小时，P<0.001），而红细胞内钠离子含量已恢复到对照水平。结果表明，这种高盐摄入导致收缩压和血浆中一种类洋地黄化合物的活性同时增加。钠钾ATP酶的抑制与收缩压和地高辛样免疫反应性相关（r = 0.569，n = 76，P<0.001和r = 0.414，n = 34，P<0.02）。（摘要截断于250字）
